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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fungal Biofilms and Polymicrobial Diseases

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Author(s):
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Costa-Orlandi, Caroline B. [1] ; Sardi, Janaina C. O. [2] ; Pitangui, Nayla S. [1] ; de Oliveira, Haroldo C. [1] ; Scorzoni, Liliana [1] ; Galeane, Mariana C. [1] ; Medina-Alarcon, Kaila P. [1] ; Melo, Wanessa C. M. A. [1] ; Marcelino, Monica Y. [1] ; Braz, Jaqueline D. [1] ; Fusco-Almeida, Ana Marisa [1] ; Mendes-Giannini, Maria Jose S. [1]
Total Authors: 12
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14800903 Araraquara, SP - Brazil
[2] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, UNICAMP, BR-13414018 Piracicaba, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: JOURNAL OF FUNGI; v. 3, n. 2 JUN 2017.
Web of Science Citations: 18
Abstract

Biofilm formation is an important virulence factor for pathogenic fungi. Both yeasts and filamentous fungi can adhere to biotic and abiotic surfaces, developing into highly organized communities that are resistant to antimicrobials and environmental conditions. In recent years, new genera of fungi have been correlated with biofilm formation. However, Candida biofilms remain the most widely studied from the morphological and molecular perspectives. Biofilms formed by yeast and filamentous fungi present differences, and studies of polymicrobial communities have become increasingly important. A key feature of resistance is the extracellular matrix, which covers and protects biofilm cells from the surrounding environment. Furthermore, to achieve cell-cell communication, microorganisms secrete quorum-sensing molecules that control their biological activities and behaviors and play a role in fungal resistance and pathogenicity. Several in vitro techniques have been developed to study fungal biofilms, from colorimetric methods to omics approaches that aim to identify new therapeutic strategies by developing new compounds to combat these microbial communities as well as new diagnostic tools to identify these complex formations in vivo. In this review, recent advances related to pathogenic fungal biofilms are addressed. (AU)

FAPESP's process: 15/03700-9 - Alternative animal as a model to study Paracoccidioides- host interaction: virulence, efficacy and toxicology of antifungal compounds and new preventive treatments
Grantee:Maria José Soares Mendes Giannini
Support Opportunities: Regular Research Grants
FAPESP's process: 15/14023-8 - Use of peptides with anti-adhesive activity in Paracoccidoides spp. in the treatment and prophylaxis of the paracoccidioidomycosis
Grantee:Haroldo Cesar de Oliveira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/10917-9 - Alternative animal models: Virulence of different phylogenetic species of Paracoccidioides and effect of the 30kDa 43kDa protein and their antibodies
Grantee:Liliana Scorzoni
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/11836-0 - SELECTION OF THERAPEUTIC TARGETS AND/OR BIOMARKERS FROM GLOBAL RESPONSE TRANSCRIPTIONAL OF ALVEOLAR MACROPHAGES INFECTED BY H. capsulatum BIOFILMS
Grantee:Ana Marisa Fusco Almeida
Support Opportunities: Regular Research Grants