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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Juvenile dermatomyositis: is periodonta disease associated with dyslipidemia?

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Autor(es):
Kozu, Katia T. [1] ; Silva, Clovis A. [1, 2] ; Aikawa, Nadia E. [2] ; Pereira, Rosa M. R. [2] ; Sallum, Adriana M. [1] ; Savioli, Cynthia [3] ; Borba, Eduardo [2] ; Campos, Lucia M. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Pediat Rheumatol Unit, Rua Joel Jorge de Melo, 600 Apto 121 Vila Mariana, BR-04128081 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Div Rheumatol, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Div Dent, Sao Paulo, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: ADVANCES IN RHEUMATOLOGY; v. 58, SEP 5 2018.
Citações Web of Science: 0
Resumo

Background: Association between periodontal disease and dyslipidemia was recently reported in healthy adults. However, a systematic evaluation of concomitant periodontal diseases and lipid profile was not carried out in juvenile dermatomyositis (JDM). A cross-section study was performed in 25 JDM patients and 25 healthy controls, assessing demographic data, periodontal evaluation, fasting lipoproteins and anti-lipoprotein lipase antibodies. Disease parameters, laboratorial tests and treatment were also evaluated in JDM patients. Results: The mean current age was similar in patients and controls (11.5 +/- 3.75 vs. 112 +/- 2.58 years,p = 0.703). Regarding lipid profile, the median triglycerides {[}80(31-340) vs. 61(19-182)mg/dL,p= 0.011] and VLDLD 6(6-68) vs. 13(4-36)mg/dL,p= 0.020] were significantly higher in JDM patients versus controls. Gingival vasculopathy pattern was significantly higher in the former group (60% vs. 0%,p = 0.0001), as well as the median of gingival bleeding index (GBI) {[}24.1(4.2-69.4) vs. 11.1(0-66.6)%,p= 0.001] and probing pocket depth (PPD) {[}1.7(0.6-2.4) vs.1.4(0-2.12) mm,p = 0.006]. Comparison between JDM patients with and without dyslipidemia revealed that the median of dental plaque index (PI) {[}100(26.7-100) vs. 59(25-100)%,p = 0.022], PPD{[}1.9(0.6-2.4) vs. 1.4(1.2-1.8)mm,p= 0.024] and clinical attachment level (CAL) {[}1.31(0.7-1.7) vs. 0.8(0.6-1.7)mm,p = 0.005] were significantly higher in patients with dyslipidemia. Further analysis between JDM patients with and without gingivitis revealed that the median of current age {[}12.4 (8.3-18.4) vs. 9.2 (5.5-17.5) years, p = 0.034] and disease duration {[}7.09 +/- 3.07 vs. 3.95 +/- 2.1 years, p = 0.008] were significantly higher in the former group. Conclusion: Our study showed that gingival inflammation seems to be related to dyslipidemia in JDM patients, suggesting underlying mechanisms for both complications. (AU)

Processo FAPESP: 08/58238-4 - Autoimunidade na criança: investigação das bases moleculares e celulares da autoimunidade de início precoce
Beneficiário:Magda Maria Sales Carneiro-Sampaio
Linha de fomento: Auxílio à Pesquisa - Temático