| Full text | |
| Author(s): |
Kozu, Katia T.
[1]
;
Silva, Clovis A.
[1, 2]
;
Aikawa, Nadia E.
[2]
;
Pereira, Rosa M. R.
[2]
;
Sallum, Adriana M.
[1]
;
Savioli, Cynthia
[3]
;
Borba, Eduardo
[2]
;
Campos, Lucia M.
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Pediat Rheumatol Unit, Rua Joel Jorge de Melo, 600 Apto 121 Vila Mariana, BR-04128081 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Div Rheumatol, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Div Dent, Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | ADVANCES IN RHEUMATOLOGY; v. 58, SEP 5 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
Background: Association between periodontal disease and dyslipidemia was recently reported in healthy adults. However, a systematic evaluation of concomitant periodontal diseases and lipid profile was not carried out in juvenile dermatomyositis (JDM). A cross-section study was performed in 25 JDM patients and 25 healthy controls, assessing demographic data, periodontal evaluation, fasting lipoproteins and anti-lipoprotein lipase antibodies. Disease parameters, laboratorial tests and treatment were also evaluated in JDM patients. Results: The mean current age was similar in patients and controls (11.5 +/- 3.75 vs. 112 +/- 2.58 years,p = 0.703). Regarding lipid profile, the median triglycerides {[}80(31-340) vs. 61(19-182)mg/dL,p= 0.011] and VLDLD 6(6-68) vs. 13(4-36)mg/dL,p= 0.020] were significantly higher in JDM patients versus controls. Gingival vasculopathy pattern was significantly higher in the former group (60% vs. 0%,p = 0.0001), as well as the median of gingival bleeding index (GBI) {[}24.1(4.2-69.4) vs. 11.1(0-66.6)%,p= 0.001] and probing pocket depth (PPD) {[}1.7(0.6-2.4) vs.1.4(0-2.12) mm,p = 0.006]. Comparison between JDM patients with and without dyslipidemia revealed that the median of dental plaque index (PI) {[}100(26.7-100) vs. 59(25-100)%,p = 0.022], PPD{[}1.9(0.6-2.4) vs. 1.4(1.2-1.8)mm,p= 0.024] and clinical attachment level (CAL) {[}1.31(0.7-1.7) vs. 0.8(0.6-1.7)mm,p = 0.005] were significantly higher in patients with dyslipidemia. Further analysis between JDM patients with and without gingivitis revealed that the median of current age {[}12.4 (8.3-18.4) vs. 9.2 (5.5-17.5) years, p = 0.034] and disease duration {[}7.09 +/- 3.07 vs. 3.95 +/- 2.1 years, p = 0.008] were significantly higher in the former group. Conclusion: Our study showed that gingival inflammation seems to be related to dyslipidemia in JDM patients, suggesting underlying mechanisms for both complications. (AU) | |
| FAPESP's process: | 08/58238-4 - Autoimmunity in children: investigation of the molecular and cellular bases of early onset of autoimmunity |
| Grantee: | Magda Maria Sales Carneiro-Sampaio |
| Support Opportunities: | Research Projects - Thematic Grants |