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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Co-infection between Zika and different Dengue serotypes during DENV outbreak in Brazil

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Autor(es):
Estofolete, Cassia F. [1] ; Terzian, Ana C. B. [1] ; Colombo, Tatiana E. [2] ; Guimaraes, Georgia de Freitas [1] ; Ferraz Junior, Helio C. [1] ; da Silva, Rafael A. [1] ; Greque, Gilmar V. [3] ; Nogueira, Mauricio L. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Sao Jose do Rio Preto Sch Med FAMERP, Ave Brigadeiro Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Paulista, Campus Sao Jose Rio Preto, Sao Paulo, SP - Brazil
[3] Sao Jose Do Rio Preto Reg Sch Med Fdn FUNFARME, Ave Brigadeiro Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF INFECTION AND PUBLIC HEALTH; v. 12, n. 2, p. 178-181, MAR-APR 2019.
Citações Web of Science: 1
Resumo

Background: The recent introduction of new arboviruses in the Americas, as Zika virus (ZIKV) and Chikungunya virus (CHIKV), increased the risk of outbreaks and arboviral co-infections. Herein, we report twelve cases of co-infection of ZIKV and different DENV serotypes in a city located in the northwest region of Sao Paulo State, Brazil, which is hyper-endemic to Dengue. Methods: Between January and November 2016, 1254 suspected cases of arboviral infection were available by our surveillance program in Sao Jose do Rio Preto. All suspected patients were examined and, when they were arboviral disease-suspectd, had sera separated and viral RNA analyzed by PCR/qPCR assays to determine the diagnosis of DENV 1-4, ZIKV, or CHIKV in the same samples. After the molecular results, twelve patients with ZIKV-DENV coinfection were identified and their clinical and laboratory characteristics were described. Results: The mean between symptoms onset and collected sample of 3 days. DENV-1 was identified in seven co-infected patients and DEN2 in other five. Two patients presented alarm signs of Dengue and no one was hospitalized. Conclusions: The constant presence of co-circulating arboviruses increases the chance of co-infection and demonstrates the importance of the differential diagnosis, especially during periods of arboviral outbreaks. The impact of this co-infection is known individual and collectively. (C) 2018 The Authors. Published by Elsevier Limited on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). (AU)

Processo FAPESP: 13/21719-3 - Estudo epidemiológico da dengue (sorotipos 1 a 4) em coorte prospectiva de São José do Rio Preto, São Paulo, Brasil, durante 2014 a 2018
Beneficiário:Maurício Lacerda Nogueira
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 15/12295-0 - Diagnóstico de arboviroses brasileiras e emergentes em pacientes e mosquitos em duas regiões distintas do Brasil
Beneficiário:Ana Carolina Bernardes Terzian
Linha de fomento: Bolsas no Brasil - Pós-Doutorado