Guarana (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients

Autor(es)

Nogueira Mendes, Thaise Maria ^[1] ; Murayama, Yukihisa ^[2] ; Yamaguchi, Natsumi ^[2] ; Sampaio, Geni Rodrigues ^[2] ; Brigatto Fontes, Luciana Cristina ^[1] ; Ferraz da Silva Torres, Elizabeth Aparecida ^[1] ; Tamura, Hirotoshi ^[2] ; Yonekura, Lina ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Av Dr Arnaldo 715, BR-03178200 Sao Paulo, SP - Brazil

^[2] Kagawa Univ, Fac Agr, 2393 Ikenobe, Miki, Kagawa 7610795 - Japan

• Tipo de documento: Artigo Científico
• Fonte: Journal of Functional Foods; v. 55, p. 352-361, APR 2019.
• Citações Web of Science: 2

Resumo

Guarana (Paullinia cupana) seeds are rich in flavan-3-ols (catechins) and reduce oxidative stress in humans. We determined the concentration and in vitro bioaccessibility of catechins in guarana seeds from two geographical origins, and measured their Caco-2 permeability. The effect of macronutrients on catechins' bioaccessibility and Caco-2 permeability was also evaluated. Guarana seeds from southern Bahia and Manes contained, respectively, 30.0 and 26.8 mg catechin/g, 20.2 and 20.0 mg epicatechin/g, 3.7 and 3.8 mg procyanidin B1/g, and 3.3 and 4.9 mg procyanidin B2/g. Bioaccessibility ranged between 65 and 95% for catechin monomers and 50-1400% for dimers. Casein inhibited bioaccessibility of catechin dimers, while vegetable oil improved bioaccessibility of total procyanidins. Guarana catechin monomers and dimers were able to permeate through Caco-2 cell mono layers (P-app 0.31-0.35 x 10(-6) cm/s) without effect from co-digested macronutrients. Guarana seeds are a source of highly bioaccessible catechins, which can permeate the intestinal epithelium with negligible effect from macronutrients. (AU)

• Processo FAPESP: 11/21272-3 - Interações entre componentes da dieta na capacidade antioxidante do guarana (Paullinia cupana), sob condições in vitro.
• Beneficiário: Elizabeth Aparecida Ferraz da Silva Torres
• Modalidade de apoio: Auxílio à Pesquisa - Regular