Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Guarana (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients

Full text
Author(s):
Nogueira Mendes, Thaise Maria [1] ; Murayama, Yukihisa [2] ; Yamaguchi, Natsumi [2] ; Sampaio, Geni Rodrigues [2] ; Brigatto Fontes, Luciana Cristina [1] ; Ferraz da Silva Torres, Elizabeth Aparecida [1] ; Tamura, Hirotoshi [2] ; Yonekura, Lina [2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Publ Hlth, Av Dr Arnaldo 715, BR-03178200 Sao Paulo, SP - Brazil
[2] Kagawa Univ, Fac Agr, 2393 Ikenobe, Miki, Kagawa 7610795 - Japan
Total Affiliations: 2
Document type: Journal article
Source: Journal of Functional Foods; v. 55, p. 352-361, APR 2019.
Web of Science Citations: 2
Abstract

Guarana (Paullinia cupana) seeds are rich in flavan-3-ols (catechins) and reduce oxidative stress in humans. We determined the concentration and in vitro bioaccessibility of catechins in guarana seeds from two geographical origins, and measured their Caco-2 permeability. The effect of macronutrients on catechins' bioaccessibility and Caco-2 permeability was also evaluated. Guarana seeds from southern Bahia and Manes contained, respectively, 30.0 and 26.8 mg catechin/g, 20.2 and 20.0 mg epicatechin/g, 3.7 and 3.8 mg procyanidin B1/g, and 3.3 and 4.9 mg procyanidin B2/g. Bioaccessibility ranged between 65 and 95% for catechin monomers and 50-1400% for dimers. Casein inhibited bioaccessibility of catechin dimers, while vegetable oil improved bioaccessibility of total procyanidins. Guarana catechin monomers and dimers were able to permeate through Caco-2 cell mono layers (P-app 0.31-0.35 x 10(-6) cm/s) without effect from co-digested macronutrients. Guarana seeds are a source of highly bioaccessible catechins, which can permeate the intestinal epithelium with negligible effect from macronutrients. (AU)

FAPESP's process: 11/21272-3 - Food diet components interactions and antioxidant capacity in vitro of guarana (Paullinia cupana)
Grantee:Elizabeth Aparecida Ferraz da Silva Torres
Support Opportunities: Regular Research Grants