The Impact of Variants in Genes Associated with Estradiol Synthesis on Hormone Levels and Oocyte Retrieval in Patients Who Underwent Controlled Ovarian Hyperstimulation

Autor(es)

Amaro, Aline ^[1] ; Polera, Daniela ^[1] ; dos Santos Figueiredo, Francisco Winter ^[2] ; Bianco, Bianca ^{[1, 2]} ; Christofolini, Denise Maria ^{[1, 2]} ; Barbosa, Caio Parente ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Inst Ideia Fertil Reprod Hlth, Santo Andre - Brazil

^[2] Fac Med ABC, Reprod Hlth & Populat Genet Discipline, Collect Hlth Dept, Ave Lauro Gomes, 2000 Ed CEPES, 2 Andar, Sala 101, BR-09060870 Santo Andre - Brazil

• Tipo de documento: Artigo Científico
• Fonte: GENETIC TESTING AND MOLECULAR BIOMARKERS; v. 23, n. 2, p. 145-149, FEB 1 2019.
• Citações Web of Science: 1

Resumo

Aims: To correlate differences in estradiol levels in serum and follicular fluid with genetic variants and to determine if they play a role in the results following assisted reproductive technology (ART). Patients and Methods: A cross-sectional study was developed at the Ideia Fertil Institute of Reproductive Health. Two hundred two female patients were selected and underwent controlled ovarian hyperstimulation cycles. Patients for this study were chosen based on their male partners' infertility. Genotypes of selected variants of CYP19A1, CYP17A1, HSD17, and COMT were compared to the estradiol measurements from follicular fluid and serum, as well as to the number and maturation status of the oocytes retrieved. Results: Patients with the variant homozygous genotype AA of CYP19A1 (rs10046) showed increased serum concentrations of estradiol when compared to patients with other genotypes (p = 0.005). The same polymorphism effect was not observed in follicular fluid. This CYP19A1 variant did not affect the number of oocytes recovered nor their maturation level. Conclusion: The CYP19A1 variant is associated with an estradiol imbalance in serum. Other pathways, however, may contribute to the formation of the final estradiol metabolite in follicular fluid as well as its impact on the oocyte maturation. (AU)

• Processo FAPESP: 12/16966-9 - Avaliação da frequência dos polimorfismos em genes relacionados ao metabolismo de estrógenos em mulheres inférteis e sua correlação com a síntese de estradiol folicular
• Beneficiário: Aline Amaro dos Santos
• Linha de fomento: Bolsas no Brasil - Mestrado
• Processo FAPESP: 10/16274-4 - Avaliação de polimorfismos genéticos em mulheres inférteis, sua correlação com a síntese de estradiol e homocisteína folicular e sérica e com resultados de reprodução assistida
• Beneficiário: Caio Parente Barbosa
• Linha de fomento: Auxílio à Pesquisa - Regular