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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Chronic intermittent ethanol administration differentially alters DeltaFosB immunoreactivity in cortical-limbic structures of rats with high and low alcohol preference

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Autor(es):
Wscieklica, Tatiana [1] ; Le Sueur-Maluf, Luciana [1] ; Prearo, Leandro [2] ; Conte, Rafael [3] ; Viana, Milena de Barros [1] ; Cespedes, Isabel Cristina [4]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo UNIFESP, Dept Biociencias, Santos, SP - Brazil
[2] Univ Municipal Sao Caetano Do Sul USCS, Proreitor Grad, Sao Caetano do Sul, SP - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Neurociencias & Neurocirurgia, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo UNIFESP, Dept Morfol & Genet, Sao Paulo, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE; v. 45, n. 3, p. 264-275, MAY 4 2019.
Citações Web of Science: 1
Resumo

Background: The role of specific cerebral areas involved in alcohol use disorder, such as the amygdala, hippocampus and prefrontal cortex, has emerged as a subject of interest over recent years. Nevertheless, the role played by these regions is frequently confounded by different variables, among them are the patterns of alcohol consumption presented by the subjects. Objectives: The present study verified the effects of chronic voluntary ethanol intake (20 sessions) on DeltaFosB immunoreactivity (DeltaFosB-ir) in the amygdala, hippocampus and prefrontal cortex of rats showing high and low preference for ethanol. Methods: DeltaFosB-ir induced by chronic voluntary ethanol intake with a two-bottle intermittent access to 20% ethanol model in male Wistar rats was measured. Three groups of animals were analyzed: control (n = 6), low preference (n = 8) and high preference (n = 8) for ethanol, the latter two categorized from their pattern of voluntary consumption of the alcohol solution. Results: Ethanol intake in high-preference rats increased DeltaFosB-ir in the central amygdala, CA1 and CA3 regions of the hippocampus and decreased DeltaFosB-ir in the prelimbic cortex and anterior cingulate cortex. On the other hand, in low preference rats, chronic voluntary ethanol intake decreased DeltaFosB-ir in the medial amygdala, basolateral amygdala, dentate gyrus and anterior cingulate cortex. Conclusions: The present results suggest that different alcohol intake patterns are associated with a specific pattern of DeltaFosB-ir in brain structures that play a key role in controlling behavior and decision making, that is the amygdala, the hippocampus and the prefrontal cortex. (AU)

Processo FAPESP: 13/01158-7 - Análise da influência do polimorfismo genético associado aos peptídeos e receptores da família CRF e do estresse ambiental no desenvolvimento da dependência de álcool
Beneficiário:Isabel Cristina Céspedes
Linha de fomento: Auxílio à Pesquisa - Regular