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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Intranasal dopamine attenuates fear responses induced by electric shock to the foot and by electrical stimulation of the dorsal periaqueductal gray matter

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Autor(es):
de Carvalho, Milene Cristina [1, 2, 3] ; de Figueiredo, Rebeca Machado [1, 2] ; Coimbra, Norberto Cysne [1, 2, 3] ; Andrade Leite-Panissi, Christie Ramos [1, 3, 4] ; de Souza Silva, Maria Angelica [5] ; Huston, Joseph P. [5] ; Mattern, Claudia [6, 7] ; Brandao, Marcus Lira [1, 3]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Inst Neurociencias & Comportamento INeC, Av Cafe, BR-2450 Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Lab Neuroanat & Neuropsychobiol, Dept Pharmacol, Ribeirao Preto Med Sch, Ribeirao Preto - Brazil
[3] Univ Sao Paulo FMRP USP, Ribeirao Preto Sch Med, NAP USP Neurobiol Emot Res Ctr NuPNE, Ribeirao Preto - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Sch Philosophy Sci & Literature, Dept Psychol, Ribeirao Preto - Brazil
[5] Univ Dusseldorf, Inst Expt Psychol, Ctr Behav Neurosci, Dusseldorf - Germany
[6] M&P Pharma AG, Emmetten - Switzerland
[7] Nova Southeastern Univ, Oceanog Ctr, Ft Lauderdale, FL 33314 - USA
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF PSYCHOPHARMACOLOGY; v. 33, n. 12 JULY 2019.
Citações Web of Science: 0
Resumo

Purpose: Intranasally applied dopamine (IN-DA), which likely reaches the brain via nasal-brain pathways and bypasses the blood-brain barrier, has been found to increase extracellular DA and bind to the DA2 transporter in the striatum. Recent studies suggest that DA plays a significant role in the processing of signaled and unconditioned aversive stimulation, including evidence that may attenuate responses to painful input. The purpose of this study was to examine the effects of IN-DA on fear-related behaviors induced by electric shock to the foot or by electrical stimulation of the dorsal periaqueductal gray matter (dPAG). Methods: DA hydrochloride suspended in a viscous castor oil gel (1 or 2 mg/kg) was applied (IN-DA) in a volume of 5 mu L into the nostrils of adult Wistar male rats in order to evaluate its effects on (a) freezing induced by electric shock to the foot and (b) thresholds of freezing and escape and duration of post-stimulation freezing induced by electrical stimulation of the dPAG. Results: IN-DA attenuated freezing induced by electric shock to the foot in the three test trials, indicating that it reduced long-term fear responses. IN-DA also increased the threshold of dPAG stimulation-induced escape responses and reduced post-stimulation freezing. Conclusions: IN-DA, which has previously been shown to facilitate learning and to have antidepressive-like effects, attenuated unconditioned fear responses elicited by peripheral and intramesencephalic (dPAG) stimulation and reduced long-term conditioned fear responses. (AU)

Processo FAPESP: 17/11855-8 - Estudo da influência de endocanabinoides do corpo estriado e do mesencéfalo ventral na atividade das projeções GABAérgicas neoestriado-nigro-tectais durante as reações de pânico de roedores ameaçados por serpentes peçonhentas
Beneficiário:Norberto Cysne Coimbra
Linha de fomento: Auxílio à Pesquisa - Regular