Beneficial Impact of Moderate to Vigorous Physical Activity Program on Circulating Number and Functional Capacity of Endothelial Progenitor Cells in Children: The Crucial Role of Nitric Oxide and VEGF-A

Autor(es)

Souza, Livia Victorino ^[1] ; De Meneck, Franciele ^[1] ; Oliveira, Vanessa ^[1] ; Higa, Elisa Mieko ^[1] ; Akamine, Eliana Hiromi ^[2] ; Franco, Maria do Carmo ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Sch Med, Div Nephrol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Pharmacol Dept, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Div Nephrol, Lab Translat Res Vasc & Mol Physiol, Sch Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PEDIATRIC EXERCISE SCIENCE; v. 31, n. 3, p. 322-329, AUG 2019.
• Citações Web of Science: 0

Resumo

Purpose: Endothelial progenitor cells (EPCs) appear to interact with physical training. This study aimed to provide a comprehensive assessment of the relationship of moderate to vigorous physical activity (MVPA) with both angiogenic factors and EPC function in healthy children. Methods: Forty children (22 boys and 18 girls) aged 7 to 11 years participated in a 10-week MVPA program (duration: 45 min; intensity: 75%-85% of heart rate reserve; frequency: 4 sessions/wk). The anthropometric data, biochemical profile, EPCs number, EPCs colony-forming units, and vascular endothelial growth factor-A (VEGF-A) and nitric oxide (NO) plasma levels were evaluated before and after the MVPA program. Results: After a 10-week MVPA program, a significant increase was detected in circulating/functional capacity of EPCs, NO, and VEGF-A levels, associated with improvement of waist circumference and estimated maximum rate of oxygen consumption (VO(2)max). A strong positive correlation was found between delta of EPCs number and variation of both NO level (r = .677, P < .001) and VEGF-A level (r = .588, P < .001). Furthermore, a significant correlation between NO level variation and delta of VEGF-A level was observed (r = .708, P < .001). Conclusion: Our findings suggest that lifestyle intervention implemented by MVPA program can contribute meaningfully to improve circulating/functional capacity of EPCs in healthy children, possibly due to the increase of plasma NO and VEGF-A levels. (AU)

• Processo FAPESP: 13/03139-0 - Inter-relação do peso ao nascer, treinamento físico e níveis pressóricos: uma abordagem clínica e experimental sobre o papel das células progenitoras endoteliais
• Beneficiário: Maria Do Carmo Pinho Franco
• Modalidade de apoio: Auxílio à Pesquisa - Regular