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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Beneficial Impact of Moderate to Vigorous Physical Activity Program on Circulating Number and Functional Capacity of Endothelial Progenitor Cells in Children: The Crucial Role of Nitric Oxide and VEGF-A

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Author(s):
Souza, Livia Victorino [1] ; De Meneck, Franciele [1] ; Oliveira, Vanessa [1] ; Higa, Elisa Mieko [1] ; Akamine, Eliana Hiromi [2] ; Franco, Maria do Carmo [3]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Sch Med, Div Nephrol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Pharmacol Dept, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Div Nephrol, Lab Translat Res Vasc & Mol Physiol, Sch Med, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PEDIATRIC EXERCISE SCIENCE; v. 31, n. 3, p. 322-329, AUG 2019.
Web of Science Citations: 0
Abstract

Purpose: Endothelial progenitor cells (EPCs) appear to interact with physical training. This study aimed to provide a comprehensive assessment of the relationship of moderate to vigorous physical activity (MVPA) with both angiogenic factors and EPC function in healthy children. Methods: Forty children (22 boys and 18 girls) aged 7 to 11 years participated in a 10-week MVPA program (duration: 45 min; intensity: 75%-85% of heart rate reserve; frequency: 4 sessions/wk). The anthropometric data, biochemical profile, EPCs number, EPCs colony-forming units, and vascular endothelial growth factor-A (VEGF-A) and nitric oxide (NO) plasma levels were evaluated before and after the MVPA program. Results: After a 10-week MVPA program, a significant increase was detected in circulating/functional capacity of EPCs, NO, and VEGF-A levels, associated with improvement of waist circumference and estimated maximum rate of oxygen consumption (VO(2)max). A strong positive correlation was found between delta of EPCs number and variation of both NO level (r = .677, P < .001) and VEGF-A level (r = .588, P < .001). Furthermore, a significant correlation between NO level variation and delta of VEGF-A level was observed (r = .708, P < .001). Conclusion: Our findings suggest that lifestyle intervention implemented by MVPA program can contribute meaningfully to improve circulating/functional capacity of EPCs in healthy children, possibly due to the increase of plasma NO and VEGF-A levels. (AU)

FAPESP's process: 13/03139-0 - The interrelationship of birth weight, physical training and blood pressure levels: a clinical and experimental approach on the role of endothelial progenitor cells
Grantee:Maria Do Carmo Pinho Franco
Support Opportunities: Regular Research Grants