Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease

Autor(es)

Mori, Marcelo A. ^[1] ; Ludwig, Raissa G. ^[1] ; Garcia-Martin, Ruben ^[2] ; Brandao, Bruna B. ^[2] ; Kahn, C. Ronald ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil

^[2] Harvard Med Sch, Sect Integrat Physiol & Metab, Joslin Diabet Ctr, Boston, MA 02115 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: Cell Metabolism; v. 30, n. 4, p. 656-673, OCT 1 2019.
• Citações Web of Science: 3

Resumo

miRNAs can be found in serum and other body fluids and serve as biomarkers for disease. More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as exosomes, may mediate paracrine and endocrine communication between different tissues and thus modulate gene expression and the function of distal cells. When impaired, these processes can lead to tissue dysfunction, aging, and disease. Adipose tissue is an especially important contributor to the pool of circulating exosomal miRNAs. As a result, alterations in adipose tissue mass or function, which occur in many metabolic conditions, can lead to changes in circulating miRNAs, which then function systemically. Here we review the findings that led to these conclusions and discuss how this sets the stage for new lines of investigation in which extracellular miRNAs are recognized as important mediators of intercellular communication and potential candidates for therapy of disease. (AU)

• Processo FAPESP: 17/23920-9 - Screening and Characterization of Circulating Molecules that Affect Energy Expenditure
• Beneficiário: Raissa Guimarães Ludwig
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/07975-8 - Explorando o papel de miRNAs circulantes derivados do tecido adiposo nos efeitos benéficos do treinamento físico
• Beneficiário: Marcelo Alves da Silva Mori
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/01184-9 - CAMeLEOm: análise entre espécies dos efeitos metabólicos, na expectativa de vida e ômicas de miméticos de restrição dietética
• Beneficiário: Marcelo Alves da Silva Mori
• Modalidade de apoio: Auxílio à Pesquisa - Temático