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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms

Texto completo
Autor(es):
da Cruz, Raquel Santana [1] ; Andrade, Fabia de Oliveira [1] ; de Oca Carioni, Vivian Montes [2] ; Rosim, Mariana Papaleo [1] ; Paulino Miranda, Mayara Lilian [1] ; Fontelles, Camile Castilho [1] ; de Oliveira, Pedro Vitoriano [2] ; Barbisan, Luis Fernando [3] ; Castro, Inar Alves [1] ; Ong, Thomas Prates [1, 4]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Food Sci & Nutr, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Dept Fundamental Chem, BR-05508000 Sao Paulo, SP - Brazil
[3] Sao Paulo State Univ UNESP, Inst Biosci Botucatu, Dept Morphol, BR-18618970 Sao Paulo, SP - Brazil
[4] Food Res Ctr FoRC, BR-05508000 Sao Paulo, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Food and Chemical Toxicology; v. 134, DEC 2019.
Citações Web of Science: 2
Resumo

Zinc is required for fetal development and is involved in key processes associated with breast carcinogenesis. We evaluated whether maternal zinc deficiency or supplementation during gestation influences female offspring susceptibility to breast cancer in adulthood. C57BL/6 mice consumed during gestation control (30 p.p.m. zinc), zinc-deficient (8 p.p.m) or zinc-supplemented (45 p.p.m.) diets. Maternal zinc supplementation increased in female mice offspring the incidence of chemically-induced mammary adenocarcinomas that were heavier, compared to control group. This was accompanied by a decreased number of terminal end buds, increased cell proliferation and apoptosis, and increased tumor suppressors p21, p53 and Rassfl, Zfp382 and Stat3 expression in mammary glands, as well as increased zinc status. Although maternal zinc deficiency did not alter the incidence of these lesions, it also induced heavier Mammary adenocarcinomas, compared to control group. These effects were accompanied by a decreased number of terminal end buds, increased proto-oncogenes c-Myc and Lmo4 expression and H3K9Me3 and H4K2OMe3 epigenetic marks in mammary glands of offspring, and decreased zinc status and increased levels of oxidative marker malondialdehyde. The data suggest that both maternal zinc deficiency and supplementation during gestation programmed increased breast cancer susceptibility in adult mice offspring following a J-shaped pattern through distinct mechanisms. (AU)

Processo FAPESP: 11/23259-4 - Nutrição materna e programação fetal do câncer de mama: importância da interação nutriente-epigenoma nas fases iniciais da vida
Beneficiário:Thomas Prates Ong
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/04960-9 - Nutrição e origem fetal do câncer de mama: efeito da deficiência ou suplementação com zinco no período gestacional de camundongos na suscetibilidade da progênie à carcinogênese mamária
Beneficiário:Raquel Santana da Cruz
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 13/07914-8 - FoRC - Centro de Pesquisa em Alimentos
Beneficiário:Bernadette Dora Gombossy de Melo Franco
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs