Effects of Polyphenol-Rich Fruit Extracts on Diet-Induced Obesity in Rodents: Systematic Review and Meta-Analysis

Autor(es)

Ballard, Cintia R. ^[1] ; Galvao, Tais F. ^[2] ; Cazarin, Cinthia B. B. ^[1] ; Marostica Jr, Mario R.

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Sch Pharmaceut Sci, Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CURRENT PHARMACEUTICAL DESIGN; v. 25, n. 32, p. 3484-3497, 2019.
• Citações Web of Science: 1

Resumo

Background: Obesity is a complex condition of high prevalence and cost to the public health system. Recent research has demonstrated the potential of natural products, such as polyphenol-rich fruit extracts, for use in the treatment of obesity. The goal of this systematic review and meta-analysis is to determine the metabolic effects of polyphenol-rich fruit extracts on diet-induced obesity (DIO) in rodents. Methods: We searched MEDLINE, EMBASE, and Web of Science databases to identify preclinical studies that assessed polyphenol-rich fruit extracts compared to placebo on DIO in rodents in December 2018. Two researchers selected the studies, extracted the data, and assessed the quality of studies. Meta-analyses of standardized mean difference (SMD) of outcomes were calculated in Stata 11, and causes of heterogeneity were assessed by meta-regression. Results: We included 14 studies in the systematic review and 13 studies with 21 matched groups in the meta-analysis. Polyphenol-rich fruit extracts reduced the total body weight gain (SMD =-1.48; confidence interval: 1.95, -1.01), energy intake (SMD =-0.42;-0.67,-0.17), visceral adipose tissue (SMD =-0.96;-1.25,-0.66), triglycerides (SMD =-1.00;-1.39,-0.62), cholesterol (SMD =-1.18,-1.66,-0.69), LDL-c (SMD =-1.15;-1.65, -0.65), fasting glucose (SMD =-1.05;-1.65,-0.46), and fasting insulin (SMD =-1.40;-1.80,-1.00) when compared to vehicle. Conclusion: Polyphenol-rich fruit extract had positive effects on weight gain, dyslipidaemia, insulin resistance at different doses, and fruit source in male mice. (AU)

• Processo FAPESP: 18/11069-5 - Ação de berries brasileiras sobre parâmetros metabólicos e desempenho cognitivo de animais obesos
• Beneficiário: Mário Roberto Maróstica Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/50333-1 - Cobra: nova plataforma de descoberta de compostos para identificação rápida e de baixo custo de bioativo com efeitos benéficos originários de plantas brasileiras
• Beneficiário: Glaucia Maria Pastore
• Modalidade de apoio: Auxílio à Pesquisa - Temático