Effects of Polyphenol-Rich Fruit Extracts on Diet-Induced Obesity in Rodents: Systematic Review and Meta-Analysis

Author(s)

Ballard, Cintia R. ^[1] ; Galvao, Tais F. ^[2] ; Cazarin, Cinthia B. B. ^[1] ; Marostica Jr, Mario R.

Affiliation

^[1] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Sch Pharmaceut Sci, Campinas, SP - Brazil

• Document type: Review article
• Source: CURRENT PHARMACEUTICAL DESIGN; v. 25, n. 32, p. 3484-3497, 2019.
• Web of Science Citations: 1

Abstract

Background: Obesity is a complex condition of high prevalence and cost to the public health system. Recent research has demonstrated the potential of natural products, such as polyphenol-rich fruit extracts, for use in the treatment of obesity. The goal of this systematic review and meta-analysis is to determine the metabolic effects of polyphenol-rich fruit extracts on diet-induced obesity (DIO) in rodents. Methods: We searched MEDLINE, EMBASE, and Web of Science databases to identify preclinical studies that assessed polyphenol-rich fruit extracts compared to placebo on DIO in rodents in December 2018. Two researchers selected the studies, extracted the data, and assessed the quality of studies. Meta-analyses of standardized mean difference (SMD) of outcomes were calculated in Stata 11, and causes of heterogeneity were assessed by meta-regression. Results: We included 14 studies in the systematic review and 13 studies with 21 matched groups in the meta-analysis. Polyphenol-rich fruit extracts reduced the total body weight gain (SMD =-1.48; confidence interval: 1.95, -1.01), energy intake (SMD =-0.42;-0.67,-0.17), visceral adipose tissue (SMD =-0.96;-1.25,-0.66), triglycerides (SMD =-1.00;-1.39,-0.62), cholesterol (SMD =-1.18,-1.66,-0.69), LDL-c (SMD =-1.15;-1.65, -0.65), fasting glucose (SMD =-1.05;-1.65,-0.46), and fasting insulin (SMD =-1.40;-1.80,-1.00) when compared to vehicle. Conclusion: Polyphenol-rich fruit extract had positive effects on weight gain, dyslipidaemia, insulin resistance at different doses, and fruit source in male mice. (AU)

• FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
• Grantee: Glaucia Maria Pastore
• Support Opportunities: Research Projects - Thematic Grants