Influence of gamma-orizanol intervention on the prevention of cardiorreanal metabo...
| Grant number: | 18/11069-5 |
| Support type: | Regular Research Grants |
| Duration: | June 01, 2019 - May 31, 2021 |
| Field of knowledge: | Health Sciences - Nutrition |
| Principal Investigator: | Mário Roberto Maróstica Junior |
| Grantee: | Mário Roberto Maróstica Junior |
| Home Institution: | Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
Abstract
Brazil has the most diverse flora in the world, which favors the discovery of edible vegetable tissues rich in bioactive compounds. The grumixama (Eugenia brasiliensis Lam.) and the cherry-of-the-rio-grande (Eugenia involucrata DC) represent sources of phenolic compounds that may potentially contribute to the prevention and treatment of chronic noncommunicable diseases such as obesity and associated comorbidities. The aim of this study is to evaluate the chemical composition and bioactivity of two Brazilian native fruits (grumixama and cherry-of-the-rio-grande) as regards anti-inflammatory, antioxidant, anti-obesogenic and neuroprotective capacity in obese animals. Swiss mice will be induced to develop obesity through a hyperlipid diet rich in saturated fatty acids. The animals will receive the lyophilized fruits (bark + pulp) added to the diets which will be fed ad libitum throughout the experimental period. The biological functionality of compounds from both fruits will be analyzed based on the determination of body weight and composition, lipid profile, hormone profile associated with hunger and satiety, insulin resistance level, serum adipokines, inflammation and oxidative stress, as well as through neurodegeneration and cognition task. The results will be analyzed by applying analysis of variance ANOVA and Tukey test for parametric data and Kruskal Wallis for non-parametric data, considering p < 0.05. The project will be executed between the first half of 2019 and the second semester of 2021. (AU)