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Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals

Grant number: 18/11069-5
Support type:Regular Research Grants
Duration: June 01, 2019 - May 31, 2021
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Mário Roberto Maróstica Junior
Grantee:Mário Roberto Maróstica Junior
Home Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated grant(s):19/13465-8 - Lund University and State University of Campinas partnership for studies on cardiometabolic disease-preventive functional foods and diets, AP.R SPRINT

Abstract

Brazil has the most diverse flora in the world, which favors the discovery of edible vegetable tissues rich in bioactive compounds. The grumixama (Eugenia brasiliensis Lam.) and the cherry-of-the-rio-grande (Eugenia involucrata DC) represent sources of phenolic compounds that may potentially contribute to the prevention and treatment of chronic noncommunicable diseases such as obesity and associated comorbidities. The aim of this study is to evaluate the chemical composition and bioactivity of two Brazilian native fruits (grumixama and cherry-of-the-rio-grande) as regards anti-inflammatory, antioxidant, anti-obesogenic and neuroprotective capacity in obese animals. Swiss mice will be induced to develop obesity through a hyperlipid diet rich in saturated fatty acids. The animals will receive the lyophilized fruits (bark + pulp) added to the diets which will be fed ad libitum throughout the experimental period. The biological functionality of compounds from both fruits will be analyzed based on the determination of body weight and composition, lipid profile, hormone profile associated with hunger and satiety, insulin resistance level, serum adipokines, inflammation and oxidative stress, as well as through neurodegeneration and cognition task. The results will be analyzed by applying analysis of variance ANOVA and Tukey test for parametric data and Kruskal Wallis for non-parametric data, considering p < 0.05. The project will be executed between the first half of 2019 and the second semester of 2021. (AU)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALEXANDRINO, THAIS DOLFINI; TOMAZINI MUNHOZ MOYA, AMANDA MARIA; MADUREIRA DE MEDEIROS, TIAGO DANIEL; MORARI, JOSEANE; VELLOSO, LICIO AUGUSTO; LEAL, RAQUEL FRANCO; MAROSTICA, MARIO ROBERTO; PASTORE, GLAUCIA MARIA; BETIM CAZARIN, CINTHIA BAU; BICAS, JULIANO LEMOS. Anti-inflammatory effects of monoterpenoids in rats with TNBS-induced colitis. PHARMANUTRITION, v. 14, DEC 2020. Web of Science Citations: 0.
ARRUDA, HENRIQUE SILVANO; NERI-NUMA, IRAMAIA ANGELICA; KIDO, LARISSA AKEMI; MAROSTICA JUNIOR, MARIO ROBERTO; PASTORE, GLAUCIA MARIA. Recent advances and possibilities for the use of plant phenolic compounds to manage ageing-related diseases. Journal of Functional Foods, v. 75, DEC 2020. Web of Science Citations: 0.
SOUZA, ALANN THAFFARELL PORTILHO; FREITAS, GILEADE PEREIRA; LOPES, HELENA BACHA; TOTOLI, GABRIELA GUARALDO CAMPOS; TARONE, ADRIANA GADIOLI; MAROSTICA-JUNIOR, MARIO ROBERTO; ROSA, ADALBERTO LUIZ; BELOTI, MARCIO MATEUS. Jabuticaba peel extract modulates adipocyte and osteoblast differentiation of MSCs from healthy and osteoporotic rats. JOURNAL OF BONE AND MINERAL METABOLISM, SEP 2020. Web of Science Citations: 0.
LAMAS, CELINA A.; KIDO, LARISSA A.; HERMES, TULIO A.; NOGUEIRA-LIMA, ELLEN; MINATEL, ELAINE; COLLARES-BUZATO, CARLA B.; MAROSTICA JR, MARIO R.; CAGNON, VALERIA H. A. Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress. PROSTATE, v. 80, n. 11 MAY 2020. Web of Science Citations: 0.
VUOLO, MILENA MORANDI; LIMA, GLAUCIA CARIELO; BATISTA, ANGELA GIOVANA; BETIM CARAZIN, CINTHIA BAU; CINTRA, DENNYS ESPER; PRADO, MARCELO ALEXANDRE; MAROSTICA JUNIOR, MARIO ROBERTO. Passion fruit peel intake decreases inflammatory response and reverts lipid peroxidation and adiposity in diet-induced obese rats. Nutrition Research, v. 76, p. 106-117, APR 2020. Web of Science Citations: 0.
BATISTA, ANGELA GIOVANA; MENDONCA, MONIQUE CULTURATO P.; SOARES, EDILENE SIQUEIRA; DA SILVA-MAIA, JULIANA KELLY; DIONISIO, ANA PAULA; SARTORI, CESAR R.; DA CRUZ-HOFLING, MARIA ALICE; MAROSTICA JUNIOR, MARIO ROBERTO. Syzygium malaccense fruit supplementation protects mice brain against high-fat diet impairment and improves cognitive functions. Journal of Functional Foods, v. 65, FEB 2020. Web of Science Citations: 0.
QUATRIN, ANDREIA; RAMPELOTTO, CRISTINE; PAULETTO, ROBERSON; MAURER, LUANA HASELEIN; NICHELLE, SABRINA MARAFIGA; KLEIN, BRUNA; RODRIGUES, RENATA FRITZSCHE; MAROSTICA JUNIOR, MARIO ROBERTO; FONSECA, BRUNA DE SOUZA; DE MENEZES, CRISTIANO RAGAGNIN; MELLO, RENIUS DE OLIVEIRA; RODRIGUES, ELISEU; BOCHI, VIVIAN CAETANO; EMANUELLI, TATIANA. Bioaccessibility and catabolism of phenolic compounds from jaboticaba (Myrciaria trunciflora) fruit peel during in vitro gastrointestinal digestion and colonic fermentation. Journal of Functional Foods, v. 65, FEB 2020. Web of Science Citations: 0.
BALLARD, CINTIA R.; GALVAO, TAIS F.; CAZARIN, CINTHIA B. B.; MAROSTICA JR, MARIO R. Effects of Polyphenol-Rich Fruit Extracts on Diet-Induced Obesity in Rodents: Systematic Review and Meta-Analysis. CURRENT PHARMACEUTICAL DESIGN, v. 25, n. 32, p. 3484-3497, 2019. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.