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Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals

Abstract

Brazil has the most diverse flora in the world, which favors the discovery of edible vegetable tissues rich in bioactive compounds. The grumixama (Eugenia brasiliensis Lam.) and the cherry-of-the-rio-grande (Eugenia involucrata DC.) represent sources of phenolic compounds that may potentially contribute to the prevention and treatment of chronic noncommunicable diseases such as obesity and associated comorbidities. The aim of this study is to evaluate the chemical composition and bioactivity of two Brazilian native fruits (grumixama and cherry-of-the-rio-grande) as regards anti-inflammatory, antioxidant, anti-obesogenic and neuroprotective capacity in obese animals. Swiss mice will be induced to develop obesity through a hyperlipid diet rich in saturated fatty acids. The animals will receive the lyophilized fruits (bark + pulp) added to the diets which will be fed ad libitum throughout the experimental period. The biological functionality of compounds from both fruits will be analyzed based on the determination of body weight and composition, lipid profile, hormone profile associated with hunger and satiety, insulin resistance level, serum adipokines, inflammation and oxidative stress, as well as through neurodegeneration and cognition task. The results will be analyzed by applying analysis of variance ANOVA and Tukey test for parametric data and Kruskal Wallis for non-parametric data, considering p < 0.05. The project will be executed between the first half of 2019 and the second semester of 2021. (AU)

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Scientific publications (26)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
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QUATRIN, ANDREIA; RAMPELOTTO, CRISTINE; PAULETTO, ROBERSON; MAURER, LUANA HASELEIN; NICHELLE, SABRINA MARAFIGA; KLEIN, BRUNA; RODRIGUES, RENATA FRITZSCHE; MAROSTICA JUNIOR, MARIO ROBERTO; FONSECA, BRUNA DE SOUZA; DE MENEZES, CRISTIANO RAGAGNIN; et al. Bioaccessibility and catabolism of phenolic compounds from jaboticaba (Myrciaria trunciflora) fruit peel during in vitro gastrointestinal digestion and colonic fermentation. Journal of Functional Foods, v. 65, . (18/11069-5, 15/50333-1)
DO NASCIMENTO, ROBERTO DE PAULA; POLEZI, GABRIELE; RIZZATO, JULIA SOTO; BATISTA, PATRICIA BERILLI; DOS SANTOS, NATHALIA MEDINA; LOUBET FILHO, PAULO SERGIO; REGUENGO, LIVIA MATEUS; MORARI, JOSEANE; JUNIOR, STANISLAU BOGUSZ; RIBEIRO PAIOTTI, ANA PAULA; et al. Brazilian berries prevent colitis induced in obese mice by reducing the clinical signs and intestinal damage. FOOD BIOSCIENCE, v. 44, n. B, . (15/50333-1, 15/13320-9, 18/11069-5)
ALEXANDRINO, THAIS DOLFINI; TOMAZINI MUNHOZ MOYA, AMANDA MARIA; MADUREIRA DE MEDEIROS, TIAGO DANIEL; MORARI, JOSEANE; VELLOSO, LICIO AUGUSTO; LEAL, RAQUEL FRANCO; MAROSTICA, MARIO ROBERTO; PASTORE, GLAUCIA MARIA; BETIM CAZARIN, CINTHIA BAU; BICAS, JULIANO LEMOS. Anti-inflammatory effects of monoterpenoids in rats with TNBS-induced colitis. PHARMANUTRITION, v. 14, . (16/21619-7, 15/50333-1, 15/13320-9, 18/11069-5)
SANZANA, SIGRID; RODRIGUEZ, LYANNE; BARRAZA BARRIONUEVO, HAYLEEN; ALBORNOZ POBLETE, CESAR; MAROSTICA JUNIOR, MARIO ROBERTO; FUENTES, EDUARDO; PALOMO, IVAN. ntiplatelet Activity of Cucurbita maxim. JOURNAL OF MEDICINAL FOOD, . (15/13320-9, 18/11069-5, 15/50333-1)
MACHADO, ANA PAULA DA FONSECA; GERALDI, MARINA VILAR; NASCIMENTO, ROBERTO DE PAULA DO; MOYA, AMANDA MARIA TOMAZINI MUNHOZ; VEZZA, TERESA; DIEZ-ECHAVE, PATRICIA; JUAN GALVAZ, JULIO; CAZARIN, CINTHIA BAU BETIM; MAROSTICA JUNIOR, MARIO ROBERTO. Polyphenols from food by-products: An alternative or complementary therapy to IBD conventional treatments. Food Research International, v. 140, . (19/12244-8, 18/11069-5, 17/23657-6, 15/50333-1)
BALLARD, CINTIA R.; GALVAO, TAIS F.; CAZARIN, CINTHIA B. B.; MAROSTICA JR, MARIO R.. Effects of Polyphenol-Rich Fruit Extracts on Diet-Induced Obesity in Rodents: Systematic Review and Meta-Analysis. CURRENT PHARMACEUTICAL DESIGN, v. 25, n. 32, p. 3484-3497, . (18/11069-5, 15/50333-1)
VUOLO, MILENA MORANDI; LIMA, GLAUCIA CARIELO; BATISTA, ANGELA GIOVANA; BETIM CARAZIN, CINTHIA BAU; CINTRA, DENNYS ESPER; PRADO, MARCELO ALEXANDRE; MAROSTICA JUNIOR, MARIO ROBERTO. Passion fruit peel intake decreases inflammatory response and reverts lipid peroxidation and adiposity in diet-induced obese rats. Nutrition Research, v. 76, p. 106-117, . (18/11069-5, 12/12322-0, 15/50333-1)
MACHADO, ANA PAULA DA FONSECA; DO NASCIMENTO, ROBERTO DE PAULA; ALVES, MARIANA DA ROCHA; REGUENGO, LIVIA MATEUS; MAROSTICA JUNIOR, MARIO ROBERTO. razilian tucuma-do-Amazonas (Astrocaryum aculeatum) and tucuma-do-Para (Astrocaryum vulgare) fruits: bioactive composition, health benefits, and technological potentia. Food Research International, v. 151, . (18/11069-5, 19/25048-2, 19/03228-9, 17/23657-6, 15/50333-1, 15/13320-9)
DE PAULA DO NASCIMENTO, ROBERTO; DA FONSECA MACHADO, ANA PAULA; LIMA, VERENA SILVA; TOMAZINI MUNHOZ MOYA, AMANDA MARIA; REGUENGO, LIVIA MATEUS; BOGUSZ JUNIOR, STANISLAU; LEAL, RAQUEL FRANCO; CAO-NGOC, PHU; ROSSI, JEAN CHRISTOPHE; LECLERCQ, LAURENT; et al. Chemoprevention with a tea from hawthorn (Crataegus oxyacantha) leaves and flowers attenuates colitis in rats by reducing inflammation and oxidative stress. FOOD CHEMISTRY-X, v. 12, . (15/50333-1, 15/13320-9, 18/11069-5, 17/23657-6)
LAMAS, CELINA A.; KIDO, LARISSA A.; HERMES, TULIO A.; NOGUEIRA-LIMA, ELLEN; MINATEL, ELAINE; COLLARES-BUZATO, CARLA B.; MAROSTICA JR, MARIO R.; CAGNON, VALERIA H. A.. Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress. PROSTATE, v. 80, n. 11, . (18/11069-5, 15/50333-1, 15/25714-1)
KIDO, LARISSA AKEMI; HAHM, EUN-RYEONG; KIM, SU-HYEONG; BASEGGIO, ANDRESSA MARA; CAGNON, VALERIA HELENA ALVES; SINGH, SHIVENDRA V.; MAROSTICA, JR., MARIO ROBERTO. Prevention of Prostate Cancer in Transgenic Adenocarcinoma of the Mouse Prostate Mice by Yellow Passion Fruit Extract and Antiproliferative Effects of Its Bioactive Compound Piceatannol. JOURNAL OF CANCER PREVENTION, v. 25, n. 2, p. 87-99, . (18/11069-5, 18/09793-7, 15/50333-1, 15/13320-9)
ARRUDA, HENRIQUE SILVANO; NERI-NUMA, IRAMAIA ANGELICA; KIDO, LARISSA AKEMI; MAROSTICA JUNIOR, MARIO ROBERTO; PASTORE, GLAUCIA MARIA. Recent advances and possibilities for the use of plant phenolic compounds to manage ageing-related diseases. Journal of Functional Foods, v. 75, . (18/11069-5, 15/13320-9, 17/01573-5, 15/50333-1)
DO NASCIMENTO, ROBERTO DE PAULA; REGUENGO, LIVIA MATEUS; DA FONSECA MACHADO, ANA PAULA; MAROSTICA JUNIOR, MARIO ROBERTO. he preventive and therapeutic potential of native Brazilian fruits on colorectal cance. FOOD BIOSCIENCE, v. 46, . (18/11069-5, 19/03228-9, 17/23657-6, 15/50333-1, 19/25048-2, 15/13320-9)
VALLE, MARIA C. P. R.; VIEIRA, ISABEL A.; FINO, LUCIANA C.; GALLINA, DARLILA A.; ESTEVES, ANDREA M.; DA CUNHA, DIOGO T.; CABRAL, LUCELIA; BENATTI, FABIANA B.; MAROSTICA JUNIOR, MARIO R.; BATISTA, ANGELA G.; et al. Immune status, well-being and gut microbiota in military supplemented with synbiotic ice cream and submitted to field training: a randomised clinical trial. BRITISH JOURNAL OF NUTRITION, v. 126, n. 12, p. 1794-1808, . (18/18366-5, 15/50333-1, 17/25007-9, 18/11069-5, 15/13320-9)
ARRUDA, HENRIQUE SILVANO; SILVA, ERIC KEVEN; PEIXOTO ARAUJO, NAYARA MACEDO; PEREIRA, GUSTAVO ARAUJO; PASTORE, GLAUCIA MARIA; MAROSTICA JUNIOR, MARIO ROBERTO. Anthocyanins Recovered from Agri-Food By-Products Using Innovative Processes: Trends, Challenges, and Perspectives for Their Application in Food Systems. Molecules, v. 26, n. 9, . (19/27103-0, 19/13465-8, 18/11069-5, 18/10608-0, 15/13320-9, 15/50333-1)
AGUIAR, LAIS MARINHO; BICAS, JULIANO LEMOS; FUENTES, EDUARDO; ALARCON, MARCELO; GONZALEZ, IVAN PALOMO; PASTORE, GLAUCIA MARIA; MAROSTICA JUNIOR, MARIO ROBERTO; CAZARIN, CINTHIA BAU BETIM. Non-nutrients and nutrients from Latin American fruits for the prevention of cardiovascular diseases. Food Research International, v. 139, . (18/11069-5, 15/50333-1, 15/13320-9)
PECANHA, JULIANA DE SOUZA; DOS SANTOS, NATHALIA MEDINA; MAROSTICA JUNIOR, MARIO ROBERTO; MICHELETTI, ANA CAMILA; LIAO, LUCIANO MORAIS; ALCANTARA, GLAUCIA BRAZ. NMR-based metabolomics of dried berries in comparison with dietary supplements. Journal of Pharmaceutical and Biomedical Analysis, v. 209, . (15/13320-9, 18/11069-5, 19/13465-8, 15/50333-1)
BASEGGIO, ANDRESSA MARA; KIDO, LARISSA AKEMI; VIGANO, JULIANE; CARNEIRO, MARA JUNQUEIRA; LAMAS, CELINA DE ALMEIDA; MARTINEZ, JULIAN; SAWAYA, ALEXANDRA CHRISTINE HELENA FRANKLAND; CAGNON, VALERIA HELENA ALVES; MAROSTICA JUNIOR, MARIO ROBERTO. Systemic antioxidant and anti-inflammatory effects of yellow passion fruit bagasse extract during prostate cancer progression. JOURNAL OF FOOD BIOCHEMISTRY, . (17/01573-5, 18/11069-5, 15/13320-9, 15/50333-1, 19/13465-8)
GERALDI, MARINA VILAR; BETIM CAZARIN, CINTHIA BAU; DIAS-AUDIBERT, FLAVIA LUISA; PEREIRA, GUSTAVO ARAUJO; CARVALHO, GABRIELA GUIMARAES; KABUKI, DIRCE YORIKA; CATHARINO, RODRIGO RAMOS; PASTORE, GLAUCIA MARIA; BEHRENS, JORGE HERMAN; CRISTIANINI, MARCELO; et al. Influence of high isostatic pressure and thermal pasteurization on chemical composition, color, antioxidant properties and sensory evaluation of jabuticaba juice. LWT-FOOD SCIENCE AND TECHNOLOGY, v. 139, . (15/13320-9, 19/12244-8, 18/11069-5, 15/50333-1)
SOUZA, ALANN THAFFARELL PORTILHO; FREITAS, GILEADE PEREIRA; LOPES, HELENA BACHA; TOTOLI, GABRIELA GUARALDO CAMPOS; TARONE, ADRIANA GADIOLI; MAROSTICA-JUNIOR, MARIO ROBERTO; ROSA, ADALBERTO LUIZ; BELOTI, MARCIO MATEUS. Jabuticaba peel extract modulates adipocyte and osteoblast differentiation of MSCs from healthy and osteoporotic rats. JOURNAL OF BONE AND MINERAL METABOLISM, v. 39, n. 2, . (15/13320-9, 17/20349-9, 18/11069-5, 15/50333-1, 17/12622-7)
DO NASCIMENTO, ROBERTO DE PAULA; MOYA, AMANDA MARIA TOMAZINI MUNHOZ; MACHADO, ANA PAULA DA FONSECA; GERALDI, MARINA VILAR; DIEZ-ECHAVE, PATRICIA; VEZZA, TERESA; GALVEZ, JULIO; CAZARIN, CINTHIA BAIL BETIM; MAROSTICA, JR., MARIO ROBERTO. Review on the potential application of non-phenolic compounds from native Latin American food byproducts in inflammatory bowel diseases. Food Research International, v. 139, . (15/50333-1, 15/13320-9, 19/12244-8, 17/23657-6, 18/11069-5)
LAIBER PASCOAL, GABRIELA DE FREITAS; DE ALMEIDA SOUSA CRUZ, MARTA ANGELA; DE ABREU, JOEL PIMENTEL; BARROS SANTOS, MILLENA CRISTINA; FANARO, GUSTAVO BERNARDES; MAROSTICA JUNIOR, MARIO ROBERTO; SILVA, OTNIEL FREITAS; ALVES MOREIRA, RICARDO FELIPE; CAMERON, LUIZ CLAUDIO; LARRAZ FERREIRA, MARIANA SIMOES; et al. Evaluation of the antioxidant capacity, volatile composition and phenolic content of hybrid Vitis vinifera L. varieties sweet sapphire and sweet surprise. Food Chemistry, v. 366, . (19/13465-8, 18/11069-5, 15/50333-1, 15/13320-9)
REGUENGO, LIVIA MATEUS; SALGACO, MATEUS KAWATA; SIVIERI, KATIA; MAROSTICA JUNIOR, MARIO ROBERTO. gro-industrial by-products: Valuable sources of bioactive compound. Food Research International, v. 152, . (15/50333-1, 19/25048-2, 18/11069-5, 15/13320-9)
BATISTA, ANGELA GIOVANA; MENDONCA, MONIQUE CULTURATO P.; SOARES, EDILENE SIQUEIRA; DA SILVA-MAIA, JULIANA KELLY; DIONISIO, ANA PAULA; SARTORI, CESAR R.; DA CRUZ-HOFLING, MARIA ALICE; MAROSTICA JUNIOR, MARIO ROBERTO. Syzygium malaccense fruit supplementation protects mice brain against high-fat diet impairment and improves cognitive functions. Journal of Functional Foods, v. 65, . (18/11069-5, 15/50333-1)
BARROS MARIUTTI, LILIAN REGINA; REBELO, KEMILLA SARMENTO; BISCONSIN-JUNIOR, ANTONIO; DE MORAIS, JANNE SANTOS; MAGNANI, MARCIANE; MALDONADE, IRIANI RODRIGUES; MADEIRA, NUNO RODRIGO; TIENGO, ANDREA; MAROSTICA, JR., MARIO ROBERTO; BETIM CAZARIN, CINTHIA BAU. The use of alternative food sources to improve health and guarantee access and food intake. Food Research International, v. 149, . (19/13465-8, 18/11069-5, 15/50333-1, 15/13320-9)

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