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Lund University and State University of Campinas partnership for studies on cardiometabolic disease-preventive functional foods and diets

Grant number: 19/13465-8
Support Opportunities:Regular Research Grants
Duration: December 01, 2019 - November 30, 2022
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Mário Roberto Maróstica Junior
Grantee:Mário Roberto Maróstica Junior
Principal researcher abroad: Juscelino Rodrigues Tovar
Institution abroad: Lund University, Lund, Sweden
Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers:Cinthia Baú Betim Cazarin
Associated research grant:18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals, AP.R


The present project aims to provide grounds for cooperation between two institutions that share interest in research in functional foods, each one exploring different aspects of the subject. The core plan will allow for a closer interaction between the two research teams, focusing on each partner's strengths and expertise on functional foods and ingredients that might be included in a cardiometabolic disease-preventive food portfolio. The Department of Food Technology, Engineering and Nutrition at Lund University (LU) houses a group of researchers with ample experience in clinical assessment of functional foods, meals and diets associated with health-promoting effects. The Nutrition section of the Department has thus comprehensive capacities to design and evaluate dietary clinical trials aiming to demonstrate the ability of foods with special metabolic effects that confer them physiological activity beyond the conventional nutritional effects (i.e. functional foods). The group has worked intensively on the evaluation and potentiating of functional features of meals and diets as means to reduce the risk for developing type 2 diabetes and cardiovascular diseases (cardiometabolic disease), always with a preventive focus. An important achievement of the group has been the development of a multifunctional dietary approach (MFD) to modulate different biomarkers associated with the propensity to cardiometabolic alterations in healthy but "at-risk" individuals. MFD is based on the synergistic action of a number of functional anti-inflammatory foods of general acceptance by the Scandinavian population (1-5). However, the suitability of the MFD approach for other cultural/geographical regions remains to be studied. DEPAN-Campinas has vast research experience in testing functional ingredients and foods using 'in vitro' systems, as well as animal models to assess the effect on inflammatory bowel disease, obesity and cognition. Brazil is immensely rich in both conventional and underutilized edible plants that gradually appear in the scientific literature as potential functional foods. Some of these materials have been already studied by the DEPAN-Campinas team (e.g. passion fruit, jaboticaba and its effects in obesity and colitis) from mechanistic and treatment points of view. Evidently, an effective cooperation between DEPAN-Campinas and LU research groups may well result in extended possibilities for improving the MFD approach, adapting it to the Brazilian reality and providing novel materials for inclusion in MFD portfolios of broader international applicability. (AU)

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Scientific publications (17)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ARRUDA, HENRIQUE SILVANO; BORSOI, FELIPE TECCHIO; ANDRADE, AMANDA CRISTINA; PASTORE, GLAUCIA MARIA; MAROSTICA JUNIOR, MARIO ROBERTO. Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.). PLANTS-BASEL, v. 12, n. 7, p. 39-pg., . (15/13320-9, 15/50333-1, 19/13465-8, 20/08761-4, 18/11069-5)
PASCOAL, GABRIELA DE FREITAS LAIBER; GERALDI, MARINA VILAR; MAROSTICA, MARIO ROBERTO, JR.; ONG, THOMAS PRATES. Effect of Paternal Diet on Spermatogenesis and Offspring Health: Focus on Epigenetics and Interventions with Food Bioactive Compounds. NUTRIENTS, v. 14, n. 10, p. 18-pg., . (15/13320-9, 18/11069-5, 19/13465-8, 15/50333-1, 19/12244-8, 13/07914-8)
CARNEIRO, MARA JUNQUEIRA; PINHEIRO, GUILHERME PEREZ; BASEGGIO, ANDRESSA MARA; MAROSTICA JR, MARIO ROBERTO; SAWAYA, ALEXANDRA CHRISTINE HELENA FRANKLAND. Chemical Composition and Antioxidant Activity of Essential Oil from Male and Female Schinus terebinthifolius. PHARMACOGNOSY RESEARCH, v. 15, n. 3, p. 8-pg., . (15/13320-9, 16/11524-9, 22/09493-9, 15/50333-1, 19/13465-8, 18/11069-5)
DA SILVA-MAIA, JULIANA KELLY; NAGALINGAM, ARUMUGAM; CAZARIN, CINTHIA BAIL BETIM; MAROSTICA JR, MARIO ROBERTO; SHARMA, DIPALI. Jaboticaba (Myrciaria jaboticaba) peel extracts induce reticulum stress and apoptosis in breast cancer cells. FOOD CHEMISTRY: MOLECULAR SCIENCES, v. 6, p. 8-pg., . (19/13465-8, 15/50333-1, 18/11069-5, 15/13320-9)
ARRUDA, HENRIQUE SILVANO; LOPES ARAUJO, MARIA VITORIA; MAROSTICA JUNIOR, MARIO ROBERTO. Underexploited Brazilian Cerrado fruits as sources of phenolic compounds for diseases management: A review. FOOD CHEMISTRY: MOLECULAR SCIENCES, v. 5, p. 22-pg., . (15/13320-9, 20/08761-4, 18/11069-5, 19/13465-8, 15/50333-1)
MARCELINO, GABRIELA; HIANE, PRISCILA AIKO; POTT, ARNILDO; DE OLIVEIRA FILIU, WANDER FERNANDO; CAIRES, ANDERSON R. L.; MICHELS, FLAVIO S.; JUNIOR, MARIO R. MAROSTICA; SANTOS, NATHALIA M. S.; NUNES, ANGELA A.; OLIVEIRA, LINCOLN C. S.; et al. Characterization of Buriti (Mauritia flexuosa) Pulp Oil and the Effect of Its Supplementation in an In Vivo Experimental Model. NUTRIENTS, v. 14, n. 12, p. 22-pg., . (15/50333-1, 15/13320-9, 18/11069-5, 19/13465-8)
BASEGGIO, ANDRESSA MARA; KIDO, LARISSA AKEMI; VIGANO, JULIANE; CARNEIRO, MARA JUNQUEIRA; LAMAS, CELINA DE ALMEIDA; MARTINEZ, JULIAN; SAWAYA, ALEXANDRA CHRISTINE HELENA FRANKLAND; CAGNON, VALERIA HELENA ALVES; MAROSTICA JUNIOR, MARIO ROBERTO. Systemic antioxidant and anti-inflammatory effects of yellow passion fruit bagasse extract during prostate cancer progression. JOURNAL OF FOOD BIOCHEMISTRY, . (17/01573-5, 18/11069-5, 15/13320-9, 15/50333-1, 19/13465-8)
CAETANO, PATRICIA A.; DO NASCIMENTO, TATIELE C.; FERNANDES, ANDRESSA S.; NASS, PRICILA P.; VIEIRA, KAREM R.; MAROSTICA JUNIOR, MARIO R.; JACOB-LOPES, EDUARDO; ZEPKA, LEILA Q.. Microalgae-based polysaccharides: Insights on production, applications, analysis, and future challenges. BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, v. 45, p. 18-pg., . (19/13465-8, 15/50333-1, 18/11069-5, 15/13320-9)
LAIBER PASCOAL, GABRIELA DE FREITAS; DE ALMEIDA SOUSA CRUZ, MARTA ANGELA; DE ABREU, JOEL PIMENTEL; BARROS SANTOS, MILLENA CRISTINA; FANARO, GUSTAVO BERNARDES; MAROSTICA JUNIOR, MARIO ROBERTO; SILVA, OTNIEL FREITAS; ALVES MOREIRA, RICARDO FELIPE; CAMERON, LUIZ CLAUDIO; LARRAZ FERREIRA, MARIANA SIMOES; et al. Evaluation of the antioxidant capacity, volatile composition and phenolic content of hybrid Vitis vinifera L. varieties sweet sapphire and sweet surprise. Food Chemistry, v. 366, . (19/13465-8, 18/11069-5, 15/50333-1, 15/13320-9)
BARROS MARIUTTI, LILIAN REGINA; REBELO, KEMILLA SARMENTO; BISCONSIN-JUNIOR, ANTONIO; DE MORAIS, JANNE SANTOS; MAGNANI, MARCIANE; MALDONADE, IRIANI RODRIGUES; MADEIRA, NUNO RODRIGO; TIENGO, ANDREA; MAROSTICA, JR., MARIO ROBERTO; BETIM CAZARIN, CINTHIA BAU. The use of alternative food sources to improve health and guarantee access and food intake. Food Research International, v. 149, . (19/13465-8, 18/11069-5, 15/50333-1, 15/13320-9)
REBELO, KEMILLA SARMENTO; COIMBRA NUNEZ, CARLA EVELYN; BETIM CAZARIN, CINTHIA BAU; MAROSTICA JUNIOR, MARIO ROBERTO; KRISTIANSEN, KARSTEN; DANNESKIOLD-SAMSOE, NIELS BANHOS. Pot-pollen supplementation reduces fasting glucose and modulates the gut microbiota in high-fat/high-sucrose fed C57BL/6 mice. FOOD & FUNCTION, v. 13, n. 7, p. 11-pg., . (15/13320-9, 15/50333-1, 19/13465-8, 18/11069-5)
ARRUDA, HENRIQUE SILVANO; SILVA, ERIC KEVEN; PEIXOTO ARAUJO, NAYARA MACEDO; PEREIRA, GUSTAVO ARAUJO; PASTORE, GLAUCIA MARIA; MAROSTICA JUNIOR, MARIO ROBERTO. Anthocyanins Recovered from Agri-Food By-Products Using Innovative Processes: Trends, Challenges, and Perspectives for Their Application in Food Systems. Molecules, v. 26, n. 9, . (19/27103-0, 19/13465-8, 18/11069-5, 18/10608-0, 15/13320-9, 15/50333-1)
KIDO, LARISSA AKEMI; ROSSETTO, ISABELA MARIA URRA; BASEGGIO, ANDRESSA MARA; CHIAROTTO, GABRIELA BORTOLANZA; ALVES, LETICIA FERREIRA; SANTOS, FELIPE RABELO; LAMAS, CELINA DE ALMEIDA; MAROSTICA, MARIO ROBERTO; CAGNON, VALERIA HELENA ALVES. Brazilian Berry Extract Differentially Induces Inflammatory and Immune Responses in Androgen Dependent and Independent Prostate Cancer Cells. JOURNAL OF CANCER PREVENTION, v. 27, n. 3, p. 10-pg., . (18/04579-7, 15/50333-1, 19/13465-8, 15/13320-9, 18/11069-5)
MOREIRA, RAFAEL CHELALA; DE MELO, RAYANNE PRISCILLA FRANCA; MARTINEZ, JULIAN; MAROSTICA JUNIOR, MARIO ROBERTO; PASTORE, GLAUCIA MARIA; ZORN, HOLGER; BICAS, JULIANO LEMOS. Supercritical CO2 as a Valuable Tool for Aroma Technology. Journal of Agricultural and Food Chemistry, v. 71, n. 24, p. 12-pg., . (21/01008-1, 15/13320-9, 20/06814-3, 17/11245-5, 15/50333-1, 19/13465-8, 18/11069-5)
PECANHA, JULIANA DE SOUZA; DOS SANTOS, NATHALIA MEDINA; MAROSTICA JUNIOR, MARIO ROBERTO; MICHELETTI, ANA CAMILA; LIAO, LUCIANO MORAIS; ALCANTARA, GLAUCIA BRAZ. NMR-based metabolomics of dried berries in comparison with dietary supplements. Journal of Pharmaceutical and Biomedical Analysis, v. 209, . (15/13320-9, 18/11069-5, 19/13465-8, 15/50333-1)

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