Low-Intensity Photobiomodulation Decreases Neuropathic Pain in Paw Ischemia-Reperfusion and Spared Nervus Ischiadicus Injury Experimental Models

Autor(es)

Pigatto, Glauce R. ^[1] ; Quinteiro, Maiara H. S. ^[1] ; Nunes-de-Souza, Ricardo L. ^[2] ; Coimbra, Norberto C. ^[3] ; Parizotto, Nivaldo A. ^{[4, 5, 1]}

Afiliação do(s) autor(es)

^[1] Univ Araraquara UNIARA, Lab Regenerat Med, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ, Sch Pharmaceut Sci, Lab Neuropsychopharmacol, UNESP, Araraquara, SP - Brazil

^[3] Univ Sao Paulo FMRP USP, Dept Pharmacol, Lab Neuroanat & Neuropsychobiol, Ribeirao Preto Med Sch, Ribeirao Preto - Brazil

^[4] Fed Univ Sao Carlos UFSCar, Dept Phys Therapy, Sao Carlos, SP - Brazil

^[5] Univ Brasil UNIBRASIL, Biomed Engn Program, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PAIN PRACTICE; v. 20, n. 4 DEC 2019.
• Citações Web of Science: 0

Resumo

Background There is a wide range of animal models available today for studying chronic pain associated with a variety of etiologies and an extensive list of clinical manifestations of peripheral neuropathies. Photobiomodulation is a new tool for the treatment of pain in a convenient, noninvasive way. Objective The aim of this work is to elucidate the effects of infrared light-emitting diodes (LEDs) on behavioral responses to nociceptive stimuli in chronic pain models. Methods Forty-eight Swiss male mice weighing 25 to 35 g were used. Two chronic pain models, ischemia-reperfusion (IR) and spared spinal nerve injury, were performed and then treated with infrared LED irradiation (390 mW, 890 nm, 17.3 mW/cm(2), 20.8 J/cm(2), for 20 minutes). The behavioral tests used were a mechanical hypersensitivity test von Frey test) and a cold allodynia test (acetone test). Results The results showed that, in the IR model, the infrared LED had a significant effect on mechanical stimulation and cold allodynia on every day of treatment. In the spared nerve injury model, an analgesic effect was observed on every treatment day (when started on the 3rd and 7th days after the surgery). In both models, the effect was abolished when the treatment was interrupted. Conclusions These findings suggest that photobiomodulation therapy may be a useful adjunct treatment for chronic pain. (AU)

• Processo FAPESP: 17/11855-8 - Estudo da influência de endocanabinoides do corpo estriado e do mesencéfalo ventral na atividade das projeções GABAérgicas neoestriado-nigro-tectais durante as reações de pânico de roedores ameaçados por serpentes peçonhentas
• Beneficiário: Norberto Cysne Coimbra
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/13941-6 - Mecanismo fotobiológico da terapia por diodo emissor de luz na dor neuropática induzida em camundongos
• Beneficiário: Glauce Regina Pigatto
• Modalidade de apoio: Bolsas no Brasil - Doutorado