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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity

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Autor(es):
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de Lima-Junior, Jose Carlos [1] ; Virginio, Vitor W. M. [1] ; Moura, Filipe A. [1, 2] ; Bertolami, Adriana [3] ; Bertolami, Marcelo [3] ; Coelho-Filho, Otavio R. [4] ; Zanotti, Ilaria [5] ; Nadruz, Wilson [4] ; de Faria, Eliana Cotta [6] ; de Carvalho, Luiz Sergio F. [4, 1] ; Sposito, Andrei C. [4, 1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Fac Med Sci, Lab Atherosclerosis & Vasc Biol, Sao Paulo - Brazil
[2] Brigham & Womens Hosp, Dept Cardiol, 75 Francis St, Boston, MA 02115 - USA
[3] Dante Pazzanese Cardiol Inst, Dept Dyslipidemia, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Cardiol Div, Sao Paulo - Brazil
[5] Univ Parma, Dept Food & Drug, Parma - Italy
[6] Univ Estadual Campinas, Fac Med Sci, Dept Clin Pathol, Lipids Lab, Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES; v. 30, n. 2, p. 254-264, FEB 10 2020.
Citações Web of Science: 0
Resumo

Background and Aim: Obesity-related decline in high-density lipoprotein (HDL) functions such as cholesterol efflux capacity (CEC) has supported the notion that this lipoprotein dysfunction may contribute for atherogenesis among obese patients. We investigated if potentially other HDL protective actions may be affected with weight gain and these changes may occur even before the obesity range in a cross-sectional analysis. Methods and Results: Lipid profile, body mass index (BMI), biochemical measurements, and carotid intima-media thickness (cIMT) were obtained in this cross-sectional study with 899 asymptomatic individuals. Lipoproteins were separated by ultracentrifugation and HDL physical-chemical characterization, CEC, antioxidant activity, anti-inflammatory activity, HDL-mediated platelet aggregation inhibition were measured in a randomly-selected subgroup (n = 101). Individuals with increased HDL-C had an attenuated increase in cIMT with elevation of BMI (interaction effect beta = -0.054; CI 95% -0.0815, -0.0301). CEC, HDL-C, HDL size and HDLantioxidant activity were negatively associated with cIMT. BMI was inversely correlated with HDL-mediated inhibition of platelet aggregation (Spearman's rho -0.157, p < 0.03) and CEC (Spearman's rho -0.32, p < 0.001), but surprisingly it was directly correlated with the antioxidant activity (Spearman's rho 0.194, p = 0.052). Thus, even in non-obese, non-diabetic individuals, increased BMI is associated with a wide change in protective functions of HDL, reducing CEC and increasing antioxidant activity. In these subjects, decreased HDL concentration, size or function are related to increased atherosclerotic burden. Conclusion: Our findings demonstrate that in non-obese, non-diabetic individuals, the increasing values of BMI are associated with impaired protective functions of HDL and concomitant increase in atherosclerotic burden. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 10/00201-8 - Relação de marcadores inflamatórios e de resistência à insulina com aterosclerose subclínica em pacientes com glicemia de jejum alterada
Beneficiário:Marcelo Chiara Bertolami
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 06/60585-9 - Relação da concentração de HDL colesterol no plasma com o metabolismo corpóreo de colesterol e em monócitos no ser humano
Beneficiário:Eder Carlos Rocha Quintão
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 12/01645-2 - Papel aditivo das características qualitativas da lipoproteína de alta densidade (HDL) à sua quantificação plasmática pelos níveis de colesterol
Beneficiário:Natália Baratella Panzoldo
Linha de fomento: Bolsas no Brasil - Doutorado Direto