Synbiotic supplementation, systemic inflammation, and symptoms of brain disorders in elders: A secondary study from a randomized clinical trial

Autor(es)

Louzada, Eliana Regina ^[1] ; Lima Ribeiro, Sandra Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Grad Program Human Appl Nutr, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRITIONAL NEUROSCIENCE; v. 23, n. 2, p. 93-100, FEB 1 2020.
• Citações Web of Science: 3

Resumo

Objectives: We aimed to investigate the effect of a symbiotic substance on symptoms of brain disorders and inflammation in the elderly. Methods: Forty-nine elders, both genders, assigned into two groups: S-group (synbiotic) and P-group (placebo). Evaluations at the beginning and at the end of the experiment: geriatric depressive symptoms scale-15 (GDS-15); mini-mental status examination (MMSE); % of body fat (%fat); serum IL-6, TNF-alpha and IL-10; serum diamine-oxidase (DAO), intestinal fatty-acid binding protein (IFABP), and lipopolysaccharide (LPS). Results: Both groups had reduced their %Fat, TNF-alpha, and DAO. The IL-6, GDS-15, and MMSE were increased in both groups. IL-10 was significantly increased only in the S-group, and LPS was significantly reduced only in the P-group. The GDS-15final was negatively explained by DAO, IL-10, TNF-alpha, %Fat, being woman, and being allocated in the P-group. The variables that positively explained the GDS-15final were the IL-6, the IFABP, and the LPS. MMSEfinal was positively associated with the IL-10, DAO, being woman, and being allocated in the P-group; and negatively associated with IL-6, TNF-alpha, %Fat, IFABP, and LPS. Conclusions: We found weak effects of symbiotic on depressive symptoms and more optimistic effects on cognition in apparently healthy elderly. Other studies, with individuals diagnosed with depressive morbidity or cognitive decline, are needed. Registration of Clinical Studies - REBEC (RBR-6qr9xx)]. (AU)

• Processo FAPESP: 12/15976-0 - Efeito da suplementação nutricional sobre a permeabilidade intestinal, a inflamação sistêmica e consequências na composição corporal de idosos
• Beneficiário: Sandra Maria Lima Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular