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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synbiotic supplementation, systemic inflammation, and symptoms of brain disorders in elders: A secondary study from a randomized clinical trial

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Author(s):
Louzada, Eliana Regina [1] ; Lima Ribeiro, Sandra Maria [1]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Grad Program Human Appl Nutr, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: NUTRITIONAL NEUROSCIENCE; v. 23, n. 2, p. 93-100, FEB 1 2020.
Web of Science Citations: 3
Abstract

Objectives: We aimed to investigate the effect of a symbiotic substance on symptoms of brain disorders and inflammation in the elderly. Methods: Forty-nine elders, both genders, assigned into two groups: S-group (synbiotic) and P-group (placebo). Evaluations at the beginning and at the end of the experiment: geriatric depressive symptoms scale-15 (GDS-15); mini-mental status examination (MMSE); % of body fat (%fat); serum IL-6, TNF-alpha and IL-10; serum diamine-oxidase (DAO), intestinal fatty-acid binding protein (IFABP), and lipopolysaccharide (LPS). Results: Both groups had reduced their %Fat, TNF-alpha, and DAO. The IL-6, GDS-15, and MMSE were increased in both groups. IL-10 was significantly increased only in the S-group, and LPS was significantly reduced only in the P-group. The GDS-15final was negatively explained by DAO, IL-10, TNF-alpha, %Fat, being woman, and being allocated in the P-group. The variables that positively explained the GDS-15final were the IL-6, the IFABP, and the LPS. MMSEfinal was positively associated with the IL-10, DAO, being woman, and being allocated in the P-group; and negatively associated with IL-6, TNF-alpha, %Fat, IFABP, and LPS. Conclusions: We found weak effects of symbiotic on depressive symptoms and more optimistic effects on cognition in apparently healthy elderly. Other studies, with individuals diagnosed with depressive morbidity or cognitive decline, are needed. Registration of Clinical Studies - REBEC (RBR-6qr9xx)]. (AU)

FAPESP's process: 12/15976-0 - Effects of nutritional suplementation on intestinal permeability, systemic low-grade inflammation and consequences on body composition in elderly individuals
Grantee:Sandra Maria Lima Ribeiro
Support Opportunities: Regular Research Grants