Silver complexes with fluoroanthranilic acid isomers: Spectroscopic characterization, antimycobacterial activity and cytotoxic studies over a panel of tumor cells

Autor(es):Mostrar menos -

Manzano, Carlos M. ^[1] ; Nakahata, Douglas H. ^[1] ; Tenorio, Juan C. ^[1] ; Lustri, Wilton R. ^[2] ; Resende Nogueira, Flavia A. ^[2] ; Aleixo, Nadia A. ^[2] ; da Silva Gomes, Pietra S. ^[2] ; Pavan, Fernando R. ^[3] ; Grecco, Julia A. ^[3] ; Ribeiro, Camila M. ^[3] ; Corbi, Pedro P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Inst Chem, Inorgan Chem Dept, POB 6154, BR-13083970 Campinas, SP - Brazil

^[2] Univ Araraquara UNIARA, Biol & Hlth Sci Dept, BR-14801320 Araraquara, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Inorganica Chimica Acta; v. 502, MAR 1 2020.
• Citações Web of Science: 3

Resumo

This manuscript presents three silver(I) complexes with fluoroanthranilic acid (fa) isomers, {[}Ag(4fa)](n), {[}Ag (5fa)](n), and {[}Ag(6fa)](n), which were named as Ag4fa, Ag5fa and Ag6fa, respectively. The 1:1 metal/ligand molar composition of the complexes was determined by elemental, thermal and high-resolution mass spectrometric (ESI( + )-MS) analyses. Infrared and H-1, C-13 and [N-15, H-1] nuclear magnetic resonance spectroscopy evidenced the coordination of the fluoroanthranilic acid isomers to silver via the nitrogen atom of the amino group and by the oxygen atoms of the carboxylate group. The structure of the Ag5fa complex was determined by single crystal X-ray diffraction analysis. The complex forms an extended polymeric structure organized in layers with coordination by the amino and carboxylate moieties. Antibacterial activity assays showed that the silver complexes were active against M. tuberculosis (MIC90 between 2.6 and 4.2 mu g/mL) and also over S. aureus, B. cereus, E. coll. and P. aeruginosa (MIC = 62.25 mu g/mL) strains. The complexes have also shown in vitro cytotoxicity over cancer cell lines and selectivity (SI) especially against epithelial colorectal adenocarcinoma cells (IC50 = 2.1 mu g/mL and SI > 3). Also, the silver complexes are non-mutagenic, which is essential when considering the development of new bioactive compounds for therapeutic purposes. (AU)

• Processo FAPESP: 18/00163-0 - Desenvolvimento e busca de novos antimicrobianos contra Tuberculose: da triagem a estudos pré-clínicos in vivo
• Beneficiário: Fernando Rogério Pavan
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/12062-4 - Síntese, caracterização e estudos de interação com biomoléculas de complexos metálicos contendo ligantes biologicamente ativos: uma estratégia na preparação de novos agentes com atividades antibacterianas e antivirais
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/16278-9 - Estudo do potencial genotoxicológico e da permeabilidade em células Caco-2 de complexos metálicos com promissoras atividades biológicas
• Beneficiário: Flávia Aparecida Resende Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/25995-6 - Novos complexos metálicos de Ag(I), Pd(II) e Pt(II) com ligantes utilizados no tratamento da Tuberculose: síntese e avaliação in vitro das atividades antimicrobiana e antiproliferativa
• Beneficiário: Carlos Marrote Manzano
• Modalidade de apoio: Bolsas no Brasil - Doutorado