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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Afferent innervation of the ischemic kidney contributes to renal dysfunction in renovascular hypertensive rats

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Autor(es):
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Lopes, Nathalia R. [1] ; Milanez, Maycon I. O. [1] ; Martins, Beatriz S. [1] ; Veiga, Amanda C. [1] ; Ferreira, Giovanna R. [1] ; Gomes, Guiomar N. [1] ; Girardi, Adriana C. [2] ; Carvalho, Polliane M. [3] ; Nogueira, Fernando N. [3] ; Campos, Ruy R. [1] ; Bergamaschi, Cassia T. [1] ; Nishi, Erika E. [1, 4]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Physiol, Escola Paulista Med, EPM, UNIFESP, Sao Paulo - Brazil
[2] Univ Sao Paulo, Heart Inst InCor, Med Sch, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dent Fac, Dept Biomat & Oral Biol, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Physiol, Cardiovasc & Resp Physiol Div, EPM, UNIFESP, Rua Botucatu 862, BR-04023060 Sao Paulo, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY; v. 472, n. 3 JAN 2020.
Citações Web of Science: 1
Resumo

The ablation of renal nerves, by destroying both the sympathetic and afferent fibers, has been shown to be effective in lowering blood pressure in resistant hypertensive patients. However, experimental studies have reported that the removal of sympathetic fibers may lead to side effects, such as the impairment of compensatory cardiorenal responses during a hemodynamic challenge. In the present study, we evaluated the effects of the selective removal of renal afferent fibers on arterial hypertension, renal sympathetic nerve activity, and renal changes in a model of renovascular hypertension. After 4 weeks of clipping the left renal artery, afferent renal denervation (ARD) was performed by exposing the left renal nerve to a 33 mM capsaicin solution for 15 min. After 2 weeks of ARD, we found reduced MAP (18%) and sympathoexcitation to both the ischemic and contralateral kidneys in the hypertensive group. Moreover, a reduction in reactive oxygen species was observed in the ischemic (76%) and contralateral (27%) kidneys in the 2K1C group. In addition, ARD normalized renal function markers and proteinuria and podocin in the contralateral kidney. Taken altogether, we show that the selective removal of afferent fibers is an effective method to reduce MAP and improve renal changes without compromising the function of renal sympathetic fibers in the 2K1C model. Renal afferent nerves may be a new target in neurogenic hypertension and renal dysfunction. (AU)

Processo FAPESP: 15/23858-6 - Efeitos da denervação renal sobre o estresse oxidativo renal na hipertensão renovascular experimental
Beneficiário:Nathalia Rodrigues Lopes
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 18/02671-3 - Ações funcionais e moleculares do nervo renal na doença renal crônica experimental
Beneficiário:Cassia Marta de Toledo Bergamaschi
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/22140-7 - Bases moleculares da função e da disfunção tubular renal
Beneficiário:Adriana Castello Costa Girardi
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 17/12383-2 - Avaliação dos efeitos cardiovasculares e renais da denervação seletiva dos aferentes renais de Ratos Wistar 2 rins, 1 clipe
Beneficiário:Nathalia Rodrigues Lopes
Linha de fomento: Bolsas no Brasil - Mestrado