The Complex Network between MYC Oncogene and microRNAs in Gastric Cancer: An Overview

Autor(es)

Anauate, Ana Carolina ^{[1, 2]} ; Leal, Mariana Ferreira ^[1] ; Queiroz Calcagno, Danielle ^[3] ; Gigek, Carolina Oliveira ^{[1, 4]} ; Real Karia, Bruno Takao ^[1] ; Wisnieski, Fernanda ^{[1, 5]} ; dos Santos, Leonardo Caires ^[1] ; Chen, Elizabeth Suchi ^[1] ; Burbano, Rommel Rodriguez ^{[3, 6, 7]} ; Cardoso Smith, Marilia Arruda ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Morfol & Genet, Disciplina Genet, BR-04023062 Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Med, Disciplina Nefrol, BR-04023062 Sao Paulo, SP - Brazil

^[3] Univ Fed Para, Hosp Univ Joao de Barros Barreto, Nucleo Pesquisas Oncol, BR-66075110 Belem, PA - Brazil

^[4] Univ Fed Sao Paulo, Dept Patol, BR-04023062 Sao Paulo, SP - Brazil

^[5] Univ Fed Sao Paulo, Dept Med, Disciplina Gastroenterol, BR-04023062 Sao Paulo, SP - Brazil

^[6] Univ Fed Para, Inst Ciencias Biol, Lab Citogenet Humana, BR-66075110 Belem, PA - Brazil

^[7] Hosp Ophir Loyola, Lab Biol Mol, BR-66063240 Belem, PA - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 21, n. 5 MAR 2020.
• Citações Web of Science: 0

Resumo

Despite the advancements in cancer treatments, gastric cancer is still one of the leading causes of death worldwide. In this context, it is of great interest to discover new and more effective ways of treating this disease. Accumulated evidences have demonstrated the amplification of 8q24.21 region in gastric tumors. Furthermore, this is the region where the widely known MYC oncogene and different microRNAs are located. MYC deregulation is key in tumorigenesis in various types of tissues, once it is associated with cell proliferation, survival, and drug resistance. microRNAs are a class of noncoding RNAs that negatively regulate the protein translation, and which deregulation is related with gastric cancer development. However, little is understood about the interactions between microRNAs and MYC. Here, we overview the MYC role and its relationship with the microRNAs network in gastric cancer aiming to identify potential targets useful to be used in clinic, not only as biomarkers, but also as molecules for development of promising therapies. (AU)

• Processo FAPESP: 16/19953-6 - Genes modulados epigeneticamente poderão constituir alvos terapêuticos em pacientes com câncer gástrico?
• Beneficiário: Fernanda Wisnieski
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/25562-0 - Abordagem molecular e funcional no câncer gástrico da população brasileira
• Beneficiário: Marilia de Arruda Cardoso Smith
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/20592-6 - INVESTIGAÇÃO DE miRNAS DIFERENCIALMENTE EXPRESSOS EM SORO DE PACIENTES COM ADENOCARCINOMA GÁSTRICO
• Beneficiário: Bruno Takao Real Karia
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/14768-5 - Afecções ortopédicas não traumáticas de ombro: aspectos genéticos e moleculares
• Beneficiário: Mariana Ferreira Leal
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores