Cytokine profile in first-episode psychosis, unaffected siblings and community-based controls: the effects of familial liability and childhood maltreatment

Autor(es)

Corsi-Zuelli, Fabiana ^{[1, 2]} ; Loureiro, Camila Marcelino ^[3] ; Shuhama, Rosana ^[2] ; Fachim, Helene Aparecida ^{[4, 2]} ; Menezes, Paulo Rossi ^[5] ; Louzada-Junior, Paulo ^[3] ; Mondelli, Valeria ^[1] ; Del-Ben, Cristina Marta ^[2]

Afiliação do(s) autor(es)

^[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London - England

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, Div Psychiat, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Div Clin Immunol, Sao Paulo - Brazil

^[4] Sheffield Hallam Univ, Biomol Sci Res Ctr, Sheffield, S Yorkshire - England

^[5] Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PSYCHOLOGICAL MEDICINE; v. 50, n. 7, p. 1139-1147, MAY 2020.
• Citações Web of Science: 2

Resumo

Background Inflammation is a possible biological mechanism underlying the association between childhood maltreatment and psychosis. Previous investigations on this regard were mainly conducted on chronic schizophrenia and lacked control for confounders. We aim to investigate the role of familial liability, childhood maltreatment and recent stress in determining cytokine abnormalities at the onset of psychosis. Methods We recruited 114 first-episode psychosis (FEP) patients, 57 unaffected biological siblings of FEP patients, and 251 community-based controls. Plasma cytokines (IL-1 beta, IL-6, TNF-alpha, IFN-gamma, IL-4, IL-10 and TGF-beta) were measured and differences across the groups analysed after adjusting for potential confounders. Results FEP had a higher pro- and anti-inflammatory cytokine profile (IL-1 beta, IL-6, TNF-alpha, IL-10 and TGF-beta), which was not observed in unaffected siblings. Siblings presented decreased IL-1 beta when compared with patients and controls. Childhood maltreatment was associated with higher levels of TGF-beta in both patients and siblings when compared with controls. Physical childhood abuse was associated with increased levels of TGF-beta in FEP patients but with decreased levels in controls. Other childhood maltreatment subtypes or recent stressors did not affect cytokine levels in any of the groups. Conclusions Normal or reduced cytokines in siblings represent possibly a protective factor and suggest that the identified inflammatory profile in FEP can be a real pathophysiological component of psychosis. Experience of childhood maltreatment may contribute as long-term immune priming for the TGF-beta pathway, and increased levels of this cytokine in both patients and siblings exposed to childhood maltreatment point to a possible biological candidate of familial risk for psychosis. (AU)

• Processo FAPESP: 12/05178-0 - Esquizofrenia e outros transtornos psicóticos: determinantes sociais e biológicos
• Beneficiário: Paulo Rossi Menezes
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/12195-9 - Influência do estresse precoce no perfil inflamatório de pacientes em Primeiro Episódio Psicótico (PEP) e no modelo animal de isolamento social a partir do desmame
• Beneficiário: Fabiana Maria das Graças Corsi Zuelli
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/11167-3 - Interações genético-ambientais na Esquizofrenia e outros transtornos psicóticos
• Beneficiário: Rosana Shuhama
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/08216-2 - CPDI - Centro de Pesquisa em Doenças Inflamatórias
• Beneficiário: Fernando de Queiroz Cunha
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 17/17480-6 - Influência do estresse precoce no perfil inflamatório de pacientes em Primeiro Episódio Psicótico (PEP) e no modelo animal de isolamento social a partir do desmame.
• Beneficiário: Fabiana Maria das Graças Corsi Zuelli
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Mestrado
• Processo FAPESP: 15/02948-7 - Estudo das alterações epigenéticas na neurotransmissão GABAérgica na esquizofrenia e outras psicoses e no modelo animal de isolamento social a partir do desmame
• Beneficiário: Helene Aparecida Fachim
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado