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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cytokine profile in first-episode psychosis, unaffected siblings and community-based controls: the effects of familial liability and childhood maltreatment

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Author(s):
Corsi-Zuelli, Fabiana [1, 2] ; Loureiro, Camila Marcelino [3] ; Shuhama, Rosana [2] ; Fachim, Helene Aparecida [4, 2] ; Menezes, Paulo Rossi [5] ; Louzada-Junior, Paulo [3] ; Mondelli, Valeria [1] ; Del-Ben, Cristina Marta [2]
Total Authors: 8
Affiliation:
[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London - England
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, Div Psychiat, Sao Paulo - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Div Clin Immunol, Sao Paulo - Brazil
[4] Sheffield Hallam Univ, Biomol Sci Res Ctr, Sheffield, S Yorkshire - England
[5] Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: PSYCHOLOGICAL MEDICINE; v. 50, n. 7, p. 1139-1147, MAY 2020.
Web of Science Citations: 2
Abstract

Background Inflammation is a possible biological mechanism underlying the association between childhood maltreatment and psychosis. Previous investigations on this regard were mainly conducted on chronic schizophrenia and lacked control for confounders. We aim to investigate the role of familial liability, childhood maltreatment and recent stress in determining cytokine abnormalities at the onset of psychosis. Methods We recruited 114 first-episode psychosis (FEP) patients, 57 unaffected biological siblings of FEP patients, and 251 community-based controls. Plasma cytokines (IL-1 beta, IL-6, TNF-alpha, IFN-gamma, IL-4, IL-10 and TGF-beta) were measured and differences across the groups analysed after adjusting for potential confounders. Results FEP had a higher pro- and anti-inflammatory cytokine profile (IL-1 beta, IL-6, TNF-alpha, IL-10 and TGF-beta), which was not observed in unaffected siblings. Siblings presented decreased IL-1 beta when compared with patients and controls. Childhood maltreatment was associated with higher levels of TGF-beta in both patients and siblings when compared with controls. Physical childhood abuse was associated with increased levels of TGF-beta in FEP patients but with decreased levels in controls. Other childhood maltreatment subtypes or recent stressors did not affect cytokine levels in any of the groups. Conclusions Normal or reduced cytokines in siblings represent possibly a protective factor and suggest that the identified inflammatory profile in FEP can be a real pathophysiological component of psychosis. Experience of childhood maltreatment may contribute as long-term immune priming for the TGF-beta pathway, and increased levels of this cytokine in both patients and siblings exposed to childhood maltreatment point to a possible biological candidate of familial risk for psychosis. (AU)

FAPESP's process: 12/05178-0 - Schizophrenia and other psychotic disorders: social and biological determinants
Grantee:Paulo Rossi Menezes
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/12195-9 - Impact of early life stress in the inflammatory profile of first episode of psychosis (FEP) patients and in the animal model of post-weaning social isolation
Grantee:Fabiana Maria das Graças Corsi Zuelli
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 13/11167-3 - Gene-environment interactions in Schizophrenia and other psychotic disorders
Grantee:Rosana Shuhama
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/08216-2 - CRID - Center for Research in Inflammatory Diseases
Grantee:Fernando de Queiroz Cunha
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 17/17480-6 - Impact of early life stress in the inflammatory profile of first episode of psychosis (FEP) patients and in the animal model of post-weaning social isolation
Grantee:Fabiana Maria das Graças Corsi Zuelli
Support Opportunities: Scholarships abroad - Research Internship - Master's degree
FAPESP's process: 15/02948-7 - Study of epigenetic alterations in GABAergic neurotransmission in schizophrenia and other psychoses and in animals undergoing social isolation from weaning
Grantee:Helene Aparecida Fachim
Support Opportunities: Scholarships in Brazil - Post-Doctoral