Silver(I) and gold(I) complexes with sulfasalazine: Spectroscopic characterization, theoretical studies and antiproliferative activities over Gram-positive and Gram-negative bacterial strains

Autor(es)

Fiori-Duarte, Ana Thereza ^{[1, 2]} ; de Paiva, Raphael Enoque F. ^[3] ; Manzano, Carlos M. ^[1] ; Lustri, Wilton R. ^[4] ; Corbi, Pedro P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Inst Chem, POB 6154, BR-13083970 Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Fac Pharmaceut Sci, BR-13083871 Campinas, SP - Brazil

^[3] Univ Sao Paulo, Inst Chem, BR-05508000 Sao Paulo, SP - Brazil

^[4] Dept Univ Araraquara UNIARA, Biol & Hlth Sci Dept Pharm Practice, BR-14801320 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Molecular Structure; v. 1214, AUG 15 2020.
• Citações Web of Science: 0

Resumo

The emergence of bacterial strains resistant to antibiotics, such as the sulfonamides (sulfa drugs), is currently a case of concern. The synthesis of metal complexes using well-known antibacterial agents and bioactive metals has proven to be an excellent strategy in the development of new and more active metallodrugs. Herein, we report the synthesis, structural characterization and antibacterial analysis of new gold(I) and silver(I) complexes with the sulfa drug sulfasalazine (ssz). Elemental, thermal and high-resolution mass spectrometric measurements indicated a 1:1:1 Au/ssz/Ph3P molar composition for the gold(I) complex (Ph3P - triphenylphosphine), while for the silver(I) complex the molar composition was 1:1 Ag/ssz. Solution state NMR and infrared spectroscopic data suggest that ssz coordinates to silver(I) and gold(I) by the oxygen atoms of the deprotonated carboxylic group. The coordination mode of the carboxylate was supported by density functional theory (DFT) calculations, which reinforces a monodentate coordination for the gold(I) complex and a bridged bidentate mode for the silver(I) one, with the molecular formulas {[}(Ph3P)Au(ssz)] and {[}Ag(ssz)](2), respectively. Antibacterial activity assays indicated the sensitivity of Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacterial strains to {[}Ag(ssz)](2) and {[}(Ph3P)Au(ssz)] complexes, while the free ligand was not able to inhibit the growth of any tested bacteria. The non-interaction of the complexes with deoxyribonucleic acid (DNA) was also demonstrated, which suggests that this biomolecule is not a preferential target for the compounds. (C) 2020 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 18/12062-4 - Síntese, caracterização e estudos de interação com biomoléculas de complexos metálicos contendo ligantes biologicamente ativos: uma estratégia na preparação de novos agentes com atividades antibacterianas e antivirais
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/12590-0 - Síntese de complexos metálicos com ligantes bioativos N,N ou N,O-coordenantes para utilização em dispositivos de liberação sustentada baseados em celulose bacteriana
• Beneficiário: Wilton Rogério Lustri
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/25995-6 - Novos complexos metálicos de Ag(I), Pd(II) e Pt(II) com ligantes utilizados no tratamento da Tuberculose: síntese e avaliação in vitro das atividades antimicrobiana e antiproliferativa
• Beneficiário: Carlos Marrote Manzano
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 15/09833-0 - Dispositivos de liberação sustentada baseados em biocelulose/complexos metálicos com ligantes bioativos
• Beneficiário: Wilton Rogério Lustri
• Modalidade de apoio: Auxílio à Pesquisa - Regular