Serum levels of matrix metalloproteinase-2,-9, and vitamin D in patients with multiple sclerosis with or without herpesvirus-6 seropositivity

Autor(es)

Amini, Razieh ^[1] ; Karampoor, Sajad ^[2] ; Zahednasab, Hamid ^[3] ; Keyuani, Hossein ^[2] ; Gheiasian, Masoud ^[4] ; Jalilian, Farid Azizi ^[5]

Afiliação do(s) autor(es)

^[1] Hamadan Univ Med Sci, Fac Med, Dept Mol Med & Genet, Hamadan, Hamadan - Iran

^[2] Iran Univ Med Sci, Sch Med, Dept Virol, Tehran - Iran

^[3] Univ Tehran, Inst Biochem & Biophys, Tehran - Iran

^[4] Hamadan Univ Med Sci, Fac Med, Dept Neurol, Hamadan, Hamadan - Iran

^[5] Hamadan Univ Med Sci, Fac Med Hamadan, Dept Med Virol, Hamadan, Hamadan - Iran

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Infectious Diseases; v. 24, n. 2, p. 144-159, MAR-APR 2020.
• Citações Web of Science: 0

Resumo

In recent years, extreme attention has been focused on the role of human herpesvirus-6 (HHV-6) in multiple sclerosis (MS) pathogenesis. However, the pathogenesis of MS associated with HHV-6 infection remains unknown. In this study, we measured the serum levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection. Five hundred sixty (including 300 females and 260 males) MS patients along with 560 healthy subjects were analyzed for HHV-6 seropositivity using enzyme-linked immunosorbent assay (ELISA). Subsequently, we measured the serum levels of MMP-2, MMP-9, and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection by ELISA. About 90.7% of MS patients (508/560) were seropositive for HHV-6, while 82.3% (461/560) of healthy subjects were seropositive for this virus (p = 0.001). Moreover, there was a significant increase in the levels of MMP-2, MMP-9, and lower vitamin D in the serum samples of MS patients when compared with healthy subjects. Additionally, we demonstrated that the MMP-9 levels in seropositive MS patients were significantly higher than seronegative MS patients (p = 0.001). Finally, our results demonstrated that the mean of expanded disability status scale (EDSS) in seropositive MS patients was significantly higher in comparison to seronegative MS patients (p <0.05). In conclusion, we suggest that the HHV-6 infection may play a role in MS pathogenesis. (C) 2020 Sociedade Brasileira de Infectologia. Published by Elsevier Espana, S.L.U. (AU)

• Processo FAPESP: 13/11323-5 - Uso de vacina de células dendríticas em associação com estratégias para eliminação de reservatórios virais almejando a cura esterilizante da infecção pelo HIV-1 em pessoas cronicamente infectadas em uso de tratamento antirretroviral
• Beneficiário: Ricardo Sobhie Diaz
• Modalidade de apoio: Auxílio à Pesquisa - Regular