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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Serum levels of matrix metalloproteinase-2,-9, and vitamin D in patients with multiple sclerosis with or without herpesvirus-6 seropositivity

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Author(s):
Amini, Razieh [1] ; Karampoor, Sajad [2] ; Zahednasab, Hamid [3] ; Keyuani, Hossein [2] ; Gheiasian, Masoud [4] ; Jalilian, Farid Azizi [5]
Total Authors: 6
Affiliation:
[1] Hamadan Univ Med Sci, Fac Med, Dept Mol Med & Genet, Hamadan, Hamadan - Iran
[2] Iran Univ Med Sci, Sch Med, Dept Virol, Tehran - Iran
[3] Univ Tehran, Inst Biochem & Biophys, Tehran - Iran
[4] Hamadan Univ Med Sci, Fac Med, Dept Neurol, Hamadan, Hamadan - Iran
[5] Hamadan Univ Med Sci, Fac Med Hamadan, Dept Med Virol, Hamadan, Hamadan - Iran
Total Affiliations: 5
Document type: Journal article
Source: Brazilian Journal of Infectious Diseases; v. 24, n. 2, p. 144-159, MAR-APR 2020.
Web of Science Citations: 0
Abstract

In recent years, extreme attention has been focused on the role of human herpesvirus-6 (HHV-6) in multiple sclerosis (MS) pathogenesis. However, the pathogenesis of MS associated with HHV-6 infection remains unknown. In this study, we measured the serum levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection. Five hundred sixty (including 300 females and 260 males) MS patients along with 560 healthy subjects were analyzed for HHV-6 seropositivity using enzyme-linked immunosorbent assay (ELISA). Subsequently, we measured the serum levels of MMP-2, MMP-9, and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection by ELISA. About 90.7% of MS patients (508/560) were seropositive for HHV-6, while 82.3% (461/560) of healthy subjects were seropositive for this virus (p = 0.001). Moreover, there was a significant increase in the levels of MMP-2, MMP-9, and lower vitamin D in the serum samples of MS patients when compared with healthy subjects. Additionally, we demonstrated that the MMP-9 levels in seropositive MS patients were significantly higher than seronegative MS patients (p = 0.001). Finally, our results demonstrated that the mean of expanded disability status scale (EDSS) in seropositive MS patients was significantly higher in comparison to seronegative MS patients (p <0.05). In conclusion, we suggest that the HHV-6 infection may play a role in MS pathogenesis. (C) 2020 Sociedade Brasileira de Infectologia. Published by Elsevier Espana, S.L.U. (AU)

FAPESP's process: 13/11323-5 - Multi interventional study exploring HIV-1 residual replication: a step towards HIV-1 eradication and sterilizing cure
Grantee:Ricardo Sobhie Diaz
Support Opportunities: Regular Research Grants