Impact of Vitamin D treatment and brain neurotrophic factor level on spatio-temporal parameters and cortical activity during gait in people with multiple sclerosis

• Grant number: 18/18078-0
• Support type: Scholarships in Brazil - Master
• Effective date (Start): December 01, 2018
• Effective date (End): September 30, 2020
• Field of knowledge: Health Sciences - Physical Education
• Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal researcher: Fabio Augusto Barbieri
• Grantee: Felipe Balistieri Santinelli
• Home Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
• Associated scholarship(s): 19/22887-3 - Relationship between gait living activities parameters obtained by accelerometers and biomarkers (BDNF) in people with multiple sclerosis, BE.EP.MS

Abstract

Multiple sclerosis (MS) is a neurodegenerative disease that causes many deficits in gait and cortical activation could be related to alterations on Brain Derived Neurotrophic Factor (BDNF) concentrations and with vitamin D deficiency. The objective of the present study is to investigate the impact of BDNF and the vitamin D treatment in the brain activity and on gait spatiotemporal parameter in people with MS. Two experiments will be accomplished. For the first experiment, thirty people with MS and thirty neurologically healthy people will accomplish blood collections to measure the BDNF blood concentrations. On the second experiment, thirty and two people with MS, 16 with vitamin D intake and 16 people without vitamin D intake and sixteen neurologically healthy people will be recruited. For both experiments, the participants will accomplish twenty gait trials (10 with obstacle crossing and 10 without obstacle crossing). The Vicon Motion System® with sample frequency of 200 Hz will be used to acquisition of spatio-temporal parameters and an electroencephalogram (eegosportstm, ANT Neuro, Enschede, Netherlands) with sample frequency of 1024 Hz, will be used to acquisition of brain activity during the protocol of gait trials. To respond the question of the first experiment, Pearson correlations will be performed between BDNF concentrations and brain activity and spatial-temporal parameters during gait performance. For the second experiment, ANOVA two-way with factor for group (MS with vitamin D intake group x MS without vitamin D intake group x control group) and gait condition (flat terrain x obstacle) will be accomplished to verify the impact of vitamin on gait parameters and brain activity.