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Antunes, Geiza Fernanda
[1]
;
Gouveia, Flavia Venetucci
[1, 2]
;
Rezende, Fabiana Strambio
[1, 2]
;
de Jesus Seno, Midia Dias
[1, 2]
;
de Carvalho, Milene Cristina
[3, 4]
;
de Oliveira, Caroline Cruz
[1, 2]
;
Tosati dos Santos, Lennon Cardoso
[1, 2]
;
de Castro, Marina Correia
[1, 2]
;
Kuroki, Mayra Akemi
[1, 2]
;
Teixeira, Manoel Jacobsen
[5]
;
Otoch, Jose Pinhata
[6]
;
Brandao, Marcus Lira
[3, 4]
;
Fonoff, Erich Talamoni
[5]
;
Ruiz Martinez, Raquel Chacon
[1, 2, 7, 8]
Número total de Autores: 14
|
| Afiliação do(s) autor(es): | [1] Hosp Sirio Libanes, Div Neurosci, Sao Paulo - Brazil
[2] Ruiz Martinez, Raquel Chacon, Univ Cidade Sao Paulo, UNICID, Sao Paulo, Brazil.Antunes, Geiza Fernanda, Hosp Sirio Libanes, Div Neurosci, Sao Paulo - Brazil
[3] Univ Sao Paulo, Campus USP, Ribeirao Preto - Brazil
[4] Inst Neurosci & Behav INeC, Campus USP, Ribeirao Preto - Brazil
[5] Univ Sao Paulo, Inst Psychiat, Dept Neurol, Div Funct Neurosurg, Sch Med, Sao Paulo - Brazil
[6] Univ Sao Paulo, Sch Med, Dept Surg Tech, Sao Paulo - Brazil
[7] Univ Sao Paulo, Inst Psychiat, LIM 23, Lab Psicopatol & Terapeut Psiquiatr, Sch Med, Sao Paulo - Brazil
[8] Univ Cidade Sao Paulo, UNICID, Sao Paulo - Brazil
Número total de Afiliações: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NEUROBIOLOGY OF STRESS; v. 12, MAY 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Avoidance behavior is a hallmark in pathological anxiety disorders and results in impairment of daily activities. Individual differences in avoidance responses are critical in determining vulnerability or resistance to anxiety disorders. Dopaminergic activation is implicated in the processing of avoidance responses; however, the mechanisms underlying these responses are unknown. In this sense, we used a preclinical model of avoidance behavior to investigate the possibility of an intrinsic differential dopaminergic pattern between good and poor performers. The specific goal was to assess the participation of dopamine (DA) through pharmacological manipulation, and we further evaluated the effects of systemic injections of the dopaminergic receptor type 1 (D1 antagonist - SCH23390) and dopaminergic receptor type 2 (D2 antagonist - sulpiride) antagonists in the good performers. Additionally, we evaluated the effects of intra-amygdala microinjection of a D1 antagonist (SCH23390) and a D2 antagonist (sulpiride) in good performers as well as intra-amygdala microinjection of a D1 agonist (SKF38393) and D2 agonist (quinpirole) in poor performers. Furthermore, we quantified the contents of dopamine and metabolites (3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)) in the amygdala, evaluated the basal levels of tyrosine hydroxylase expression (catecholamine synthesis enzyme) and measured the volume of the substantia nigra, ventral tegmental area and locus coeruleus. Our results showed that it could be possible to convert animals from good to poor performers, and vice versa, by intra-amygdala (basolateral and central nucleus) injections of D1 receptor antagonists in good performers or D2 receptor agonists in poor performers. Additionally, the good performers had lower levels of DOPAC and HVA in the amygdala, an increase in the total volume of the amygdala (AMG), substantia nigra (SN), ventral tegmental area (VTA) and locus coeruleus (LC), and an increase in the number of tyrosine hydroxylase-positive cells in SN, VTA and LC, which positively correlates with the avoidance behavior. Taken together, our data show evidence for a dopaminergic signature of avoidance performers, emphasizing the role of distinct dopaminergic receptors in individual differences in avoidance behavior based on pharmacological, immunohistochemical, neurochemical and volumetric analyses. Our findings provide a better understanding of the role of the dopaminergic system in the execution of avoidance behavior. (AU) | |
| Processo FAPESP: | 13/03039-5 - Papel dos níveis plasmáticos de corticosterona em animais com desempenho bom e ruim no teste da aprendizagem aversiva |
| Beneficiário: | Caroline Cruz de Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 17/10466-8 - Desvendando agressividade: estudo de imagem do cérebro agressivo |
| Beneficiário: | Flavia Venetucci Gouveia |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |
| Processo FAPESP: | 13/20602-5 - Análise prospectiva dos resultados funcionais da amigdalotomia bilateral assistencial em pacientes com agressividade refratária |
| Beneficiário: | Flavia Venetucci Gouveia |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 11/08575-7 - Papel da modulação dopaminérgica no núcleo lateral da amígdala sobre a resposta condicionada de esquiva |
| Beneficiário: | Raquel Chacon Ruiz Martinez |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 13/03040-3 - Investigação dos níveis de ansiedade com o desempenho no teste da aprendizagem aversiva |
| Beneficiário: | Marina Correia de Castro |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 14/12999-5 - Avaliação do fator linhagem nos níveis de ansiedade em animais com desempenho bom e ruim no teste da aprendizagem aversiva: Wistar versus Sprague Dawley |
| Beneficiário: | Lennon Tosati Cardoso Dos Santos |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |