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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation

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Autor(es):
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Amorim, Mateus R. [1] ; de Deus, Junia L. [1] ; Pereira, Camila A. [2] ; da Silva, Luiz E. V. [2] ; Borges, Gabriela S. [2] ; Ferreira, Nathanne S. [2] ; Batalhao, Marcelo E. [3] ; Antunes-Rodrigues, Jose [2] ; Carnio, Evelin C. [3] ; Tostes, Rita C. [2] ; Branco, Luiz G. S. [1, 2]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dent Sch Ribeirao Preto, BR-14040904 Sao Paulo - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Nursing Sch Ribeirao Preto, BR-14040902 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC REPORTS; v. 10, n. 1 APR 24 2020.
Citações Web of Science: 2
Resumo

Beyond the regulation of cardiovascular function, baroreceptor afferents play polymodal roles in health and disease. Sepsis is a life-threatening condition characterized by systemic inflammation (SI) and hemodynamic dysfunction. We hypothesized that baroreceptor denervation worsens lipopolysaccharide (LPS) induced-hemodynamic collapse and SI in conscious rats. We combined: (a) hemodynamic and thermoregulatory recordings after LPS administration at a septic-like non-lethal dose (b) analysis of the cardiovascular complexity, (c) evaluation of vascular function in mesenteric resistance vessels, and (d) measurements of inflammatory cytokines (plasma and spleen). LPS-induced drop in blood pressure was higher in sino-aortic denervated (SAD) rats. LPS-induced hemodynamic collapse was associated with SAD-dependent autonomic disbalance. LPS-induced vascular dysfunction was not affected by SAD. Surprisingly, SAD blunted LPS-induced surges of plasma and spleen cytokines. These data indicate that baroreceptor afferents are key to alleviate LPS-induced hemodynamic collapse, affecting the autonomic control of cardiovascular function, without affecting resistance blood vessels. Moreover, baroreflex modulation of the LPS-induced SI and hemodynamic collapse are not dependent of each other given that baroreceptor denervation worsened hypotension and reduced SI. (AU)

Processo FAPESP: 16/17681-9 - Alterações fisiopatológicas durante a inflamação sistêmica
Beneficiário:Luiz Guilherme de Siqueira Branco
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 17/09878-0 - Efeito da estimulação vagal durante desafio imune por LPS em ratos normotensos e espontaneamente hipertensos
Beneficiário:Mateus Ramos Amorim
Linha de fomento: Bolsas no Brasil - Pós-Doutorado