Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation

Author(s):Show less -

Amorim, Mateus R. ^[1] ; de Deus, Junia L. ^[1] ; Pereira, Camila A. ^[2] ; da Silva, Luiz E. V. ^[2] ; Borges, Gabriela S. ^[2] ; Ferreira, Nathanne S. ^[2] ; Batalhao, Marcelo E. ^[3] ; Antunes-Rodrigues, Jose ^[2] ; Carnio, Evelin C. ^[3] ; Tostes, Rita C. ^[2] ; Branco, Luiz G. S. ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Dent Sch Ribeirao Preto, BR-14040904 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Nursing Sch Ribeirao Preto, BR-14040902 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 10, n. 1 APR 24 2020.
• Web of Science Citations: 2

Abstract

Beyond the regulation of cardiovascular function, baroreceptor afferents play polymodal roles in health and disease. Sepsis is a life-threatening condition characterized by systemic inflammation (SI) and hemodynamic dysfunction. We hypothesized that baroreceptor denervation worsens lipopolysaccharide (LPS) induced-hemodynamic collapse and SI in conscious rats. We combined: (a) hemodynamic and thermoregulatory recordings after LPS administration at a septic-like non-lethal dose (b) analysis of the cardiovascular complexity, (c) evaluation of vascular function in mesenteric resistance vessels, and (d) measurements of inflammatory cytokines (plasma and spleen). LPS-induced drop in blood pressure was higher in sino-aortic denervated (SAD) rats. LPS-induced hemodynamic collapse was associated with SAD-dependent autonomic disbalance. LPS-induced vascular dysfunction was not affected by SAD. Surprisingly, SAD blunted LPS-induced surges of plasma and spleen cytokines. These data indicate that baroreceptor afferents are key to alleviate LPS-induced hemodynamic collapse, affecting the autonomic control of cardiovascular function, without affecting resistance blood vessels. Moreover, baroreflex modulation of the LPS-induced SI and hemodynamic collapse are not dependent of each other given that baroreceptor denervation worsened hypotension and reduced SI. (AU)

• FAPESP's process: 17/09878-0 - Effect of vagal stimulation during LPS immune challenge in normotensive and spontaneously hypertensive rats
• Grantee: Mateus Ramos Amorim
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/17681-9 - Pathophysiological changes during systemic inflammation
• Grantee: Luiz Guilherme de Siqueira Branco
• Support Opportunities: Research Projects - Thematic Grants