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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation

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Author(s):
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Amorim, Mateus R. [1] ; de Deus, Junia L. [1] ; Pereira, Camila A. [2] ; da Silva, Luiz E. V. [2] ; Borges, Gabriela S. [2] ; Ferreira, Nathanne S. [2] ; Batalhao, Marcelo E. [3] ; Antunes-Rodrigues, Jose [2] ; Carnio, Evelin C. [3] ; Tostes, Rita C. [2] ; Branco, Luiz G. S. [1, 2]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Dent Sch Ribeirao Preto, BR-14040904 Sao Paulo - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Nursing Sch Ribeirao Preto, BR-14040902 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 10, n. 1 APR 24 2020.
Web of Science Citations: 2
Abstract

Beyond the regulation of cardiovascular function, baroreceptor afferents play polymodal roles in health and disease. Sepsis is a life-threatening condition characterized by systemic inflammation (SI) and hemodynamic dysfunction. We hypothesized that baroreceptor denervation worsens lipopolysaccharide (LPS) induced-hemodynamic collapse and SI in conscious rats. We combined: (a) hemodynamic and thermoregulatory recordings after LPS administration at a septic-like non-lethal dose (b) analysis of the cardiovascular complexity, (c) evaluation of vascular function in mesenteric resistance vessels, and (d) measurements of inflammatory cytokines (plasma and spleen). LPS-induced drop in blood pressure was higher in sino-aortic denervated (SAD) rats. LPS-induced hemodynamic collapse was associated with SAD-dependent autonomic disbalance. LPS-induced vascular dysfunction was not affected by SAD. Surprisingly, SAD blunted LPS-induced surges of plasma and spleen cytokines. These data indicate that baroreceptor afferents are key to alleviate LPS-induced hemodynamic collapse, affecting the autonomic control of cardiovascular function, without affecting resistance blood vessels. Moreover, baroreflex modulation of the LPS-induced SI and hemodynamic collapse are not dependent of each other given that baroreceptor denervation worsened hypotension and reduced SI. (AU)

FAPESP's process: 17/09878-0 - Effect of vagal stimulation during LPS immune challenge in normotensive and spontaneously hypertensive rats
Grantee:Mateus Ramos Amorim
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/17681-9 - Pathophysiological changes during systemic inflammation
Grantee:Luiz Guilherme de Siqueira Branco
Support Opportunities: Research Projects - Thematic Grants