Pathophysiological changes during systemic inflammation

• Grant number: 16/17681-9
• Support Opportunities: Research Projects - Thematic Grants
• Start date: February 01, 2017
• End date: August 31, 2022
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Luiz Guilherme de Siqueira Branco
• Grantee: Luiz Guilherme de Siqueira Branco
• Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Pesquisadores principais: Evelin Capellari Cárnio
• Associated scholarship(s): 22/01783-8 - Effects of fluoxetine pretreatment on endotoxemia-induced hypothermia, BP.MS; 21/05371-3 - Anti-inflammatory action of angiotensin-(1-7) on cardiovascular complications induced by experimental Sepsis, BP.DD; 21/10152-9 - Pathophysiological changes during systemic inflammation, BP.TT; + associated scholarships 20/15022-3 - Characterization of Clostridium beijerinkii Br21 as a probiotic and psychobiotic, BP.PD; 21/03084-7 - Pathophysiological changes during systemic inflammation, BP.TT; 20/12777-3 - "Interaction between Angiotensin-converting enzyme 2 and serotonin during systemic inflammation", BP.PD; 20/11003-4 - Anti-inflammatory action of the renin-angiotensin system in fever and hypothermia during experimental sepsis, BP.IC; 19/27231-9 - Effect of fluvoxamine on neuroimmune alterations in septic rats, BP.PD; 19/00832-2 - Relation between body temperature and nitric oxide in rats undergoing septic shock, BP.IC; 18/18459-3 - Physiopathological changes during systemic inflammation, BP.TT; 18/14226-4 - The role of the inflammatory reflex in the endotoxin tolerance, BP.IC; 17/01633-8 - Role of serotonin in the preoptic area in the modulation of body temperature and nociception during systemic inflammation, BP.DR; 17/09878-0 - Effect of vagal stimulation during LPS immune challenge in normotensive and spontaneously hypertensive rats, BP.PD; 17/03645-3 - Role of hydrogen sulfide in orofacial allodynia modulation in an experimental model of arterial hypertension, BP.IC; 17/04644-0 - The role of central serotonin modulating mechanical and thermal nociception during systemic inflammation, BP.IC; 17/04610-9 - Citral on euthymia and fever, BP.IC - associated scholarships

Abstract

The systemic inflammatory response syndrome (SIRS) is an inflammatory condition that affects the whole body and represents a serious threat. Endotoxemia, sepsis and its complications (septic shock and multiple organ failure) are the major cause of death in intensive care units worldwide, despite recent major technological advances. Lack of knowledge of the pathophysiological mechanisms of this condition and the aging population are facts related to this situation. In recent years, we settled in our laboratories an experimental model to unravel the mechanisms involved in immune responses to the endotoxin challenge more specifically we assessed the participation of gaseous neuromodulators (nitric oxide, carbon monoxide and hydrogen sulfide) in the central nervous system. We have published articles in peer reviewed journals and chapters in books; facts that reinforce recognition of the world front scientific community to our work. This proposal aims to improve the efficiency of our work, enabling the increase in the number of students and researchers involved, expanding knowledge about the nervous, hormonal, cardiovascular, thermoregulatory and behavioral changes that take place during and after experimental systemic inflammation induced by endotoxin. (AU)

Scientific publications

(35)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JACOB SABINO, JOAO PAULO; DE CASTRO OLIVEIRA, LUCAS VAZ; SORIANO, RENATO NERY; KWIATKOSKI, MARCELO; BRANCO, LUIZ G. S.; DA SILVA, GLAUBER S. F.. Role of hydrogen sulfide in ventilatory responses to hypercapnia in the medullary raphe of adult rats. Experimental Physiology, JUL 2021. (11/14779-4, 15/24950-3, 16/17681-9)

DE MELLO ROSA, GUSTAVO HENRIQUE; ULLAH, FARHAD; DE PAIVA, YARA BEZERRA; DA SILVA, JULIANA ALMEIDA; BRANCO, LUIZ GUILHERME S.; CORRADO, ALEXANDRE PINTO; MEDEIROS, PRISCILA; COIMBRA, NORBERTO CYSNE; BIAGIONI, AUDREY FRANCESCHI. Ventrolateral periaqueductal gray matter integrative system of defense and antinociception. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 474, n. 4, p. 12-pg., 2022-02-24. (15/10313-1, 17/13560-5, 16/18218-0, 16/17681-9, 09/54014-7, 14/10742-7)

GARATTINI, EMANUELA G.; SANTOS, BRUNA M.; FERRARI, DANIELE P.; CAPEL, CAMILA P.; FRANCESCATO, HELOISA D. C.; COIMBRA, TEREZILA M.; LEITE-PANISSI, CHRISTIE R. A.; BRANCO, LUIZ G. S.; NASCIMENTO, GLAUCE C.. Propargylglycine decreases neuro-immune interaction inducing pain response in temporomandibular joint inflammation model. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 93, p. 90-101, DEC 1 2019. (15/03053-3, 17/03645-3, 16/09364-3, 16/17681-9)

AMORIM, MATEUS R.; DE DEUS, JUNIA L.; PEREIRA, CAMILA A.; DA SILVA, LUIZ E. V.; BORGES, GABRIELA S.; FERREIRA, NATHANNE S.; BATALHAO, MARCELO E.; ANTUNES-RODRIGUES, JOSE; CARNIO, EVELIN C.; TOSTES, RITA C.; et al. Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation. SCIENTIFIC REPORTS, v. 10, n. 1, APR 24 2020. (17/09878-0, 16/17681-9)

NOGUEIRA, JONATAS E.; PASSAGLIA, PATRICIA; MOTA, CLARISSA M. D.; SANTOS, BRUNA M.; BATALHAO, MARCELO E.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Molecular hydrogen reduces acute exercise-induced inflammatory and oxidative stress status. Free Radical Biology and Medicine, v. 129, p. 186-193, DEC 2018. (16/17681-9)

AMORIM, MATEUS R.; DE JESUS, ALINE A.; SANTOS-JUNIOR, NILTON N.; ROCHA, MARIA J. A.; NOGUEIRA, JONATAS E.; BATALHAO, MARCELO E.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Autonomic Disbalance During Systemic Inflammation is Associated with Oxidative Stress Changes in Sepsis Survivor Rats. Inflammation, JAN 2022. (17/09878-0, 16/17681-9)

SANTOS, BRUNA M.; NASCIMENTO, GLANCE C.; CAPEL, CAMILA P.; BORGES, GABRIELA S.; ROSOLEN, THALES; SABINO, JOAO P. J.; LEITE-PANISSI, CHRISTIE R. A.; BRANCO, LUIZ G. S.. Sex differences and the role of ovarian hormones in site-specific nociception of SHR. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 317, n. 2, p. R223-R231, AUG 2019. (17/03645-3, 16/09364-3, 16/17681-9)

NOGUEIRA, JONATAS E.; DE DEUS, JUNIA L.; AMORIM, MATEUS R.; BATALHAO, MARCELO E.; LEAO, RICARDO M.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Inhaled molecular hydrogen attenuates intense acute exercise-induced hippocampal inflammation in sedentary rats. Neuroscience Letters, v. 715, JAN 10 2020. (16/17681-9)

MOTA, CLARISSA M. D.; RODRIGUES-SANTOS, CAROLINE; CAROLINO, RUITHER O. G.; ANSELMO-FRANCI, JANETE A.; BRANCO, LUIZ G. S.. Citral-induced analgesia is associated with increased spinal serotonin, reduced spinal nociceptive signaling, and reduced systemic oxidative stress in arthritis. Journal of Ethnopharmacology, v. 250, MAR 25 2020. (17/04644-0, 16/17681-9)

FONSECA, ELISA M.; NORONHA-DE-SOUZA, CAROLINA R.; BICEGO, KENIA C.; BRANCO, LUIZ G. S.; GARGAGLIONI, LUCIANE H.. 5-HT neurons of the medullary raphe contribute to respiratory control in toads. Respiratory Physiology & Neurobiology, v. 293, NOV 2021. (19/09469-8, 16/17681-9)

NOGUEIRA, JONATAS E.; AMORIM, MATEUS R.; PINTO, ANA P.; DA ROCHA, ALISSON L.; DA SILVA, ADELINO S. R.; BRANCO, LUIZ G. S.. Molecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage. Canadian Journal of Physiology and Pharmacology, v. 99, n. 8, p. 812-820, AUG 2021. (17/09878-0, 16/17681-9, 17/19869-8, 17/12765-2)

DA SILVA JUNIOR, CARLOS APARECIDO; PATRONE, LUIS GUSTAVO A.; BIANCARDI, VIVIAN; VILELA-COSTA, HELOISA H.; MARQUES, DANUZIA A.; CRISTINA-SILVA, CAROLINE; DA COSTA SILVA, KAOMA STEPHANI; BICEGO, KENIA C.; SZAWKA, RAPHAEL E.; GARGAGLIONI, LUCIANE H.. Sexually dimorphic effects of prenatal diazepam exposure on respiratory control and the monoaminergic system of neonate and young rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 474, n. 11, p. 16-pg., 2022-07-25. (17/05318-0, 16/17681-9, 20/01702-2, 17/26367-9)

SANTOS, BRUNA M.; SANTOS, WANDERSON S.; SOLON, ISABELLY G.; GARCIA, FELIPE S.; EMILIO-SILVA, MAYCON T.; JESUS, ALINE A.; HIRUMA-LIMA, CLELIA A.; NASCIMENTO, GLAUCE C.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats. ARCHIVES OF ORAL BIOLOGY, v. 152, p. 7-pg., 2023-05-25. (16/09364-3, 16/17681-9)

AMORIM, MATEUS R.; MOREIRA, DIEGO A.; SANTOS, BRUNA M.; FERRARI, GUSTAVO D.; NOGUEIRA, JONATAS E.; DE DEUS, JUNIA L.; ALBERICI, LUCIANE C.; BRANCO, LUIZ G. S.. Increased lipopolysaccharide-induced hypothermia in neurogenic hypertension is caused by reduced hypothalamic PGE(2)production and increased heat loss. JOURNAL OF PHYSIOLOGY-LONDON, v. 598, n. 20, p. 18-pg., 2020-08-21. (17/09878-0, 16/17681-9)

SANTOS, BRUNA M.; FRANCESCATO, HELOISA D. C.; TURCATO, FLAVIA C.; ANTUNES-RODRIGUES, JOSE; COIMBRA, TEREZILA M.; BRANCO, LUIZ G. S.. Increased hypothalamic hydrogen sulphide contributes to endotoxin tolerance by down-modulating PGE(2) production. ACTA PHYSIOLOGICA, v. 228, n. 3, p. 12-pg., 2019-09-15. (16/09364-3, 16/17681-9)

AMORIM, MATEUS R.; MOREIRA, DIEGO A.; SANTOS, BRUNA M.; FERRARI, GUSTAVO D.; NOGUEIRA, JONATAS E.; DE DEUS, JUNIA L.; ALBERICI, LUCIANE C.; BRANCO, LUIZ G. S.. Increased lipopolysaccharide-induced hypothermia in neurogenic hypertension is caused by reduced hypothalamic PGE(2)production and increased heat loss. JOURNAL OF PHYSIOLOGY-LONDON, AUG 2020. (17/09878-0, 16/17681-9)

SANTOS, BRUNA M.; FRANCESCATO, HELOISA D. C.; TURCATO, FLAVIA C.; ANTUNES-RODRIGUES, JOSE; COIMBRA, TEREZILA M.; BRANCO, LUIZ G. S.. Increased hypothalamic hydrogen sulphide contributes to endotoxin tolerance by down-modulating PGE(2) production. ACTA PHYSIOLOGICA, SEP 2019. (16/09364-3, 16/17681-9)

SANTOS, BRUNA M.; COSTA, LUIS H. A.; ROCHA, MARIA J.; BRANCO, LUIZ G. S.. Central leukotrienes modulate fever tolerance to LPS in rats. Journal of Thermal Biology, v. 84, p. 245-249, AUG 2019. (16/09364-3, 16/17681-9)

COSTA, LUIS H. A.; SANTOS, BRUNA M.; BRANCO, LUIZ G. S.. Can selective serotonin reuptake inhibitors have a neuroprotective effect during COVID-19?. European Journal of Pharmacology, v. 889, DEC 15 2020. (19/27231-9, 16/17681-9)

MOTA, CLARISSA M. D.; ANTUNES-RODRIGUES, JOSE; BRANCO, LUIZ G. S.. Central fractalkine stimulates central prostaglandin E-2 production and induces systemic inflammatory responses. Brain Research Bulletin, v. 140, p. 311-317, JUN 2018. (17/01633-8, 16/17681-9)

MOTA, CLARISSA M. D.; BORGES, GABRIELA S.; AMORIM, MATEUS R.; CAROLINO, RUITHER O. G.; BATALHAO, MARCELO E.; ANSELMO-FRANCI, JANETE A.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Central serotonin prevents hypotension and hypothermia and reduces plasma and spleen cytokine levels during systemic inflammation. BRAIN BEHAVIOR AND IMMUNITY, v. 80, p. 255-265, AUG 2019. (17/09878-0, 16/17681-9)

AMORIM, MATEUS R.; DE DEUS, JUNIA L.; CAZUZA, RAFAEL A.; MOTA, CLARISSA M. D.; DA SILVA, LUIZ E. V.; BORGES, GABRIELA S.; BATALHAO, MARCELO E.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation. JOURNAL OF NEUROINFLAMMATION, v. 16, JUN 20 2019. (17/09878-0, 17/01633-8, 16/17681-9)

SORIANO, RENATO N.; BRAGA, SARA P.; BREDER, JESSICA S. C.; BATALHAO, MARCELO E.; OLIVEIRA-PELEGRIN, GABRIELA R.; FERREIRA, LUIZ FERNANDO R.; ROCHA, MARIA JOSE A.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Endogenous peripheral hydrogen sulfide is propyretic: its permissive role in brown adipose tissue thermogenesis in rats. Experimental Physiology, v. 103, n. 3, p. 397-407, MAR 1 2018. (16/17681-9, 12/01417-0, 15/24950-3)

DE DEUS, JUNIA LARA; AMORIM, MATEUS RAMOS; GAMA DE BARCELLOS FILHO, PROCOPIO CLEBER; CORTES DE OLIVEIRA, JOSE ANTONIO; BATALHAO, MARCELO EDUARDO; GARCIA-CAIRASCO, NORBERTO; CARNIO, EVELIN CAPELLARI; LEAO, RICARDO MAURICIO; DE SIQUEIRA BRANCO, LUIZ GUILHERME; SIQUEIRA CUNHA, ALEXANDRA OLIMPIO. Inflammatory markers in the hippocampus after audiogenic kindling. Neuroscience Letters, v. 721, MAR 16 2020. (17/09878-0, 15/22327-7, 16/01607-4, 16/17681-9)

JACOB SABINO, JOAO PAULO; DE CASTRO OLIVEIRA, LUCAS VAZ; SORIANO, RENATO NERY; KWIATKOSKI, MARCELO; BRANCO, LUIZ G. S.; DA SILVA, GLAUBER S. F.. Role of hydrogen sulfide in ventilatory responses to hypercapnia in the medullary raphe of adult rats. Experimental Physiology, v. 106, n. 9, p. 1992-2001, SEP 2021. (15/24950-3, 11/14779-4, 16/17681-9)

FAIM, FELIPE; PASSAGLIA, PATRICIA; BATALHAO, MARCELO; LACCHINI, RICCARDO; STABILE, ANGELITA MARIA; CARNIO, EVELIN CAPELLARI. Role of ghrelin on growth hormone/insulin-like growth factor-1 axis during endotoxemia. GROWTH HORMONE & IGF RESEARCH, v. 48-49, p. 36-44, OCT-DEC 2019. (15/09857-7, 16/17681-9)

NOGUEIRA, JONATAS E.; AGOSTINHO, BRENDA K. L.; MOTA, CLARISSA M. D.; BRANCO, LUIZ G. S.. Splenic anti-inflammatory reflex in immune tolerance. Journal of Thermal Biology, v. 85, OCT 2019. (17/01633-8, 16/17681-9)

DE DEUS, JUNIA L.; AMORIM, MATEUS R.; RIBEIRO, ALINE B.; BARCELLOS-FILHO, PROCOPIO C. G.; CEBALLOS, CESAR C.; BRANCO, LUIZ GUILHERME S.; CUNHA, ALEXANDRA O. S.; LEAO, RICARDO M.. Loss of Brain-Derived Neurotrophic Factor Mediates Inhibition of Hippocampal Long-Term Potentiation by High-Intensity Sound. Cellular and Molecular Neurobiology, v. 41, n. 4, MAY 2020. (16/17681-9, 15/22327-7, 16/01607-4)

SARAMAGO, EDUARDO A.; BORGES, GABRIELA S.; SINGOLANI-, JR., CARLITOS G.; NOGUEIRA, JONATAS E.; SORIANO, RENATO N.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Molecular hydrogen potentiates hypothermia and prevents hypotension and fever in LPS-induced systemic inflammation. BRAIN BEHAVIOR AND IMMUNITY, v. 75, p. 119-128, JAN 2019. (16/17681-9)

EMILIO-SILVA, MAYCON T.; MOTA, CLARISSA M. D.; HIRUMA-LIMA, CLELIA A.; ANTUNES-RODRIGUES, JOSE; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Antipyretic Effects of Citral and Possible Mechanisms of Action. Inflammation, v. 40, n. 5, p. 1735-1741, OCT 2017. (16/17681-9)

DE DEUS, JUNIA LARA; AMORIM, MATEUS RAMOS; DA SILVA JUNIOR, RUI MILTON PATRICIO; JESUS, ALINE ALVES; DE BARCELLOS FILHO, PROCOPIO CLEBER GAMA; CARNIO, EVELIN CAPELLARI; CUNHA, ALEXANDRA OLIMPIO SIQUEIRA; LEAO, RICARDO MAURICIO; BRANCO, LUIZ G. S.. Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates memory impairment during systemic inflammation. BRAIN, BEHAVIOR, & IMMUNITY - HEALTH, v. 31, p. 10-pg., 2023-08-01. (16/17681-9, 17/09878-0, 16/01607-4)

NOGUEIRA, JONATAS E.; BRANCO, LUIZ G. S.. Recent Advances in Molecular Hydrogen Research Reducing Exercise-Induced Oxidative Stress and Inflammation. CURRENT PHARMACEUTICAL DESIGN, v. 27, n. 5, p. 731-736, 2021. (16/17681-9)

PASSAGLIA, PATRICIA; SILVA, HADDER BATISTA; DE JESUS, ALINE ALVES; MARANGA FILHO, MARCO ANTONIO; TRAJANO, ISIS PAIVA; BATALHA, MARCELO EDUARDO; NAVEGANTES, LUIZ CARLOS CARVALHO; BRANCO, LUIZ GUILHERME SIQUEIRA; CARNIO, EVELIN CAPELLARI. Angiotensin-(1-7) improves tail skin heat loss and increases the survival of rats with polymicrobial sepsis. Peptides, v. 167, p. 9-pg., 2023-06-13. (16/17681-9, 20/11003-4)

DA SILVA JUNIOR, CARLOS APARECIDO; MARQUES, DANUZIA A.; PATRONE, LUIS GUSTAVO A.; BIANCARDI, VIVIAN; BICEGO, KENIA C.; GARGAGLIONI, LUCIANE H.. Intra-uterine diazepam exposure decreases the number of catecholaminergic and serotoninergic neurons of neonate rats. Neuroscience Letters, v. 795, p. 8-pg., 2023-01-02. (20/01702-2, 16/17681-9, 17/26367-9, 17/05318-0)

DIAS MOTA, CLARISSA MARIA; ALVES DA ROCHA, MARIA JOSE; ANTUNES-RODRIGUES, JOSE; DE SIQUEIRA BRANCO, LUIZ GUILHERME. Central Fractalkine Induces Systemic Inflammation Independently of Hypothalamic Prostaglandin E2. FASEB JOURNAL, v. 32, n. 1, p. 2-pg., 2018-04-01. (17/01633-8, 16/17681-9)