Evaluation of the anti-inflammatory potential of Solidago microglossa (Arnica-brasileira) in vivo and its effects on PPAR gamma activity

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Vogas, Rityello S. ^{[1, 2]} ; Pereira, Mariana T. M. ^{[1, 2]} ; Duarte, Luiza S. ^[2] ; Carneiro, Mara J. ^[3] ; Farsura, Andrew F. ^[2] ; Machado, Joao Augusto M. M. ^{[1, 2]} ; Costa, Ingrid F. ^[4] ; Tome, Mayara R. N. ^[4] ; Milton, Flora A. ^[5] ; Neves, Francisco A. R. ^[6] ; Andreo, Marcio Adriano ^[4] ; Lopez, Begona Gimenez-Cassina ^[7] ; Sawaya, Alexandra Christine Helena F. ^{[3, 8]} ; Bitencourt Pascoal, Vinicius D'Avila ^{[1, 2]} ; Pascoal, Aislan Cristina R. F. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Fed Fluminense, Inst Biol, Programa Posgrad Ciencias & Biotecnol, Outeiro Sao Joao Batista S-N, Campus Valonguinho, BR-24210130 Niteroi, RJ - Brazil

^[2] Univ Fed Fluminense, Inst Saude Nova Friburgo, Dept Ciencias Basicas, Rua Dr Silvio Henrique Braune 22, BR-28625650 Nova Friburgo, RJ - Brazil

^[3] Univ Estadual Campinas, Inst Biol, Programa Posgrad Biociencias & Tecnol Prod Bioact, Rua Monteiro Lobato 255, BR-13083862 Campinas, SP - Brazil

^[4] Univ Fed Sao Paulo, Dept Ciencias Farmaceut, Rua Sao Nicolau 210, BR-09913030 Diadema, SP - Brazil

^[5] Univ Brasilia, Fac Med, Area Morfol, Campus Univ Darcy Ribeiro BC-321, BR-70910900 Brasilia, DF - Brazil

^[6] Univ Brasilia, Lab Farmacol Mol, Fac Ciencias Saude, Campus Univ Darcy Ribeiro, BR-70910900 Brasilia, DF - Brazil

^[7] Havard Med Sch, Brigham & Womens Hosp, Dept Neurosurg, 75 Francis St, Boston, MA 02115 - USA

^[8] Univ Estadual Campinas, Fac Ciencias Farmaceut, R Candid Portinari 200, BR-13083871 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Anais da Academia Brasileira de Ciências; v. 92, n. 2 2020.
• Citações Web of Science: 0

Resumo

Solidago microglossa is used as an anti-inflammatory agent in traditional Brazilian medicine, and this work evaluated the anti-inflammatory potential of the crude ethanolic extract of the flowers of S. microglossa in vivo, a s assayed by paw edema models induced by carrageenan, prostaglandin E2, bradykinin and compound 48/80. In the chemical profile, we identified compounds by electrospray ionization mass spectrometry and quantified them by HPLC-DAD. Additionally, this study analyzed the potential to activate the in vitro transcriptional activity of PPAR gamma, which is a nuclear receptor linked to the anti-inflammatory response. It was possible to identify five compounds: quinic acid, quercetin, chlorogenic acid, hyperoside, and rutin. In the paw edema evaluation, it was possible to show the potential of reducing edema during the inflammatory process. The crude ethanolic extract of the flowers of S. microglossa activated PPAR gamma compared to the full agonist rosiglitazone and in a dose-response manner. It is possible to conclude that the extract of the flowers of S. microglossa showed anti-inflammatory activity, and the phenolic compounds present in this species might be responsible for this activity. (AU)

• Processo FAPESP: 08/58035-6 - Control of lignin biosynthesis in sugar cane: many gaps still to be filled
• Beneficiário: Paulo Mazzafera
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOEN - Temático