Serological evidence of Mayaro virus infection in blood donors from sao Carlos, sao Paulo, Brazil

Autor(es)

Romeiro, Marilia Farignoli ^[1] ; Fumagalli, Marcilio Jorge ^[1] ; dos Anjos Souza, Ana Beatriz ^{[1, 2]} ; Moraes Figueiredo, Luiz Tadeu ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Virol Res Ctr, Ribeirao Preto Med Sch, Ribeirao Preto, SP - Brazil

^[2] Banco Sangue Irmandade Santa Casa Misericordia Sa, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Transactions of the Royal Society of Tropical Medicine and Hygiene; v. 114, n. 9, p. 693-696, SEP 2020.
• Citações Web of Science: 1

Resumo

Background: Human infections by Mayaro virus (MAYV) occur by insect bites upon exposure to rural or sylvatic areas. Information regarding MAYV transmission is Limited due to a Lack of commercial diagnostic assays and diagnostic confusion on account of similarities of clinical signs with other co-circulating arboviral diseases. Methods: A serological survey of MAYV and Chikunguya virus (CHIKV) antibodies was performed by ELISA. Between 2017 and 2018, 5608 blood donor samples were tested. Results: Specific IgM and IgG antibodies to MAYV were detected respectively in 36 and 11 samples, indicating a total seroprevalence of approximately 0.83%. Neutralization activity was observed in two IgG positive sera. Additionally, eight distinct samples had IgM antibodies to CHIKV alone. Conclusions: Our data suggest previously unreported circulation of MAYV in Sao Carlos city, from southeastern Brazil. (AU)

• Processo FAPESP: 16/01414-1 - Produção de peptídeos recombinantes virais antigênicos e desenvolvimento de métodos sorológicos para diagnóstico de infecções pelos vírus Chikungunya, Mayaro e Zika
• Beneficiário: Marcilio Jorge Fumagalli
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 14/02438-6 - Estudos com Bunyaviridae causadores de doença
• Beneficiário: Luiz Tadeu Moraes Figueiredo
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/20851-8 - Estudo sobre infecções por Alphavirus e Flavivirus em amostras de Banco de Sangue
• Beneficiário: Marilia Farignoli Romeiro
• Modalidade de apoio: Bolsas no Brasil - Doutorado