Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine

Autor(es):Mostrar menos -

Almeida, Vitor Y. G. ^[1] ; Rocha, Josias S. ^[1] ; Felix, Debora P. ^[1] ; Oliveira, Gabriela P. ^[1] ; Lima, Mauro A. ^[1] ; Farias, Renan L. ^[2] ; Zanetti, Renan D. ^[2] ; Netto, Adelino V. G. ^[2] ; Zambom, Carolina R. ^[3] ; Garrido, Saulo S. ^[3] ; Rocha, V, Fillipe

Afiliação do(s) autor(es)

^[1] V, Univ Fed Sao Carlos, Chem Dept, Rod Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil

^[2] UNESP Univ Estadual Paulista, Inst Chem, Dept Analyt Chem Physicochem & Inorgan Chem, Av Prof Francisco Degni 55, BR-14800900 Araraquara, SP - Brazil

^[3] UNESP Univ Estadual Paulista, Inst Chem, Dept Biochem & Organ Chem, Av Prof Francisco Degni 55, BR-14800900 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHEMISTRYSELECT; v. 5, n. 46, p. 14559-14563, DEC 11 2020.
• Citações Web of Science: 0

Resumo

The present work aimed to evaluate the biological activities of the silver (I) complexes, with the formulae {[}Ag(L)(PPh3)(2)](+) and {[}Ag(L)(2)](+) (L=(E)-2-((E)-3-phenylallylidene) hydrazine-1-carboxamide - CSC and (2E)-2-{[}(3E)-4-phenylbut-3-en-2-ylidene]-hydrazinecarboxamide - BSC). Four new silver(I) compounds were synthesized and characterized by NMR H-1, C-13-[H-1], P-31, IR, and UV-Vis spectroscopies, molar conductivity, and elemental analysis (CNH). High cytotoxicity was found for all complexes being more active than cisplatin in the tested cell lines. The antibacterial assay demonstrated that the compounds without phosphine groups presented high levels of inhibition (80 %) at 70.4 uM against the Gram-positive and Gram-negative bacteria strains. The DNA interactions were investigated by UV-Vis DNA titration, electrophoresis, and circular dichroism experiments. Data showed that the compounds did not interact with DNA in the tested conditions. However, the compounds have provided important information about the structural features that are needed in order to design new silver (I) complexes with biological activities. (AU)

• Processo FAPESP: 19/17584-1 - Síntese, caracterização e avaliação da capacidade intercalativa com o DNA de complexos de Pt(II) contendo derivados da 1,10-fenantrolina
• Beneficiário: Debora Pinheiro Felix
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 18/03018-1 - Síntese química e caracterização de sistemas contendo peptídeos antimicrobianos para aplicação na área da saúde
• Beneficiário: Saulo Santesso Garrido
• Modalidade de apoio: Auxílio à Pesquisa - Regular