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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine

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Author(s):
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Almeida, Vitor Y. G. [1] ; Rocha, Josias S. [1] ; Felix, Debora P. [1] ; Oliveira, Gabriela P. [1] ; Lima, Mauro A. [1] ; Farias, Renan L. [2] ; Zanetti, Renan D. [2] ; Netto, Adelino V. G. [2] ; Zambom, Carolina R. [3] ; Garrido, Saulo S. [3] ; Rocha, V, Fillipe
Total Authors: 11
Affiliation:
[1] V, Univ Fed Sao Carlos, Chem Dept, Rod Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil
[2] UNESP Univ Estadual Paulista, Inst Chem, Dept Analyt Chem Physicochem & Inorgan Chem, Av Prof Francisco Degni 55, BR-14800900 Araraquara, SP - Brazil
[3] UNESP Univ Estadual Paulista, Inst Chem, Dept Biochem & Organ Chem, Av Prof Francisco Degni 55, BR-14800900 Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: CHEMISTRYSELECT; v. 5, n. 46, p. 14559-14563, DEC 11 2020.
Web of Science Citations: 0
Abstract

The present work aimed to evaluate the biological activities of the silver (I) complexes, with the formulae {[}Ag(L)(PPh3)(2)](+) and {[}Ag(L)(2)](+) (L=(E)-2-((E)-3-phenylallylidene) hydrazine-1-carboxamide - CSC and (2E)-2-{[}(3E)-4-phenylbut-3-en-2-ylidene]-hydrazinecarboxamide - BSC). Four new silver(I) compounds were synthesized and characterized by NMR H-1, C-13-[H-1], P-31, IR, and UV-Vis spectroscopies, molar conductivity, and elemental analysis (CNH). High cytotoxicity was found for all complexes being more active than cisplatin in the tested cell lines. The antibacterial assay demonstrated that the compounds without phosphine groups presented high levels of inhibition (80 %) at 70.4 uM against the Gram-positive and Gram-negative bacteria strains. The DNA interactions were investigated by UV-Vis DNA titration, electrophoresis, and circular dichroism experiments. Data showed that the compounds did not interact with DNA in the tested conditions. However, the compounds have provided important information about the structural features that are needed in order to design new silver (I) complexes with biological activities. (AU)

FAPESP's process: 19/17584-1 - Synthesis, characterization and evaluation of DNA intercalation capacity of Pt(II) complexes bearing 1,10-phenanthroline and derivatives
Grantee:Debora Pinheiro Felix
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/03018-1 - Chemical synthesis and characterization of systems containing antimicrobial peptides for application in health
Grantee:Saulo Santesso Garrido
Support type: Regular Research Grants