Type I interferon in the pathogenesis of systemic lupus erythematosus

Autor(es)

Postal, Mariana ^[1] ; Vivaldo, Jessica F. ^{[1, 2]} ; Fernandez-Ruiz, Ruth ^[3] ; Paredes, Jacqueline L. ^[3] ; Appenzeller, Simone ^{[1, 4]} ; Niewold, Timothy B. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Med Sci, Autoimmun Lab, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Sch Med Sci, Grad Program Child & Adolescent Hlth, Campinas, SP - Brazil

^[3] NYU, Sch Med, Colton Ctr Autoimmun, New York, NY - USA

^[4] Univ Estadual Campinas, Sch Med Sci, Dept Med, Rheumatol Unit, Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CURRENT OPINION IN IMMUNOLOGY; v. 67, p. 87-94, DEC 2020.
• Citações Web of Science: 0

Resumo

Type I interferon (IFN) is a primary pathogenic factor in systemic lupus erythematosus (SLE). Gain-of-function genetic variants in the type I IFN pathway have been associated with risk of disease. Common polygenic as well as rare monogenic influences on type I IFN have been demonstrated, supporting a complex genetic basis for high IFN in many SLE patients. Both SLE-associated autoantibodies and high type I IFN can be observed in the pre-disease state. Patients with SLE and evidence of high type I IFN have more active disease and a greater propensity to nephritis and other severe manifestations. Despite the well-established association between type I IFN and SLE, the specific triggers of type I IFN production, the mechanisms by which IFNs help perpetuate the cycle of autoreactive cells and autoantibody production are not completely clear. This review provides an updated overview of type I IFN in SLE pathogenesis, clinical manifestations, and current therapeutic strategies targeting this pathway. (AU)

• Processo FAPESP: 08/02917-0 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no lúpus eritematoso sistêmico
• Beneficiário: Simone Appenzeller
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 16/23269-3 - MicroRNAs do gene TNFa no lúpus eritematoso sistêmico: potenciais biomarcadores
• Beneficiário: Mariana Postal Zink de Souza
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado