| Full text | |
| Author(s): |
Postal, Mariana
[1]
;
Vivaldo, Jessica F.
[1, 2]
;
Fernandez-Ruiz, Ruth
[3]
;
Paredes, Jacqueline L.
[3]
;
Appenzeller, Simone
[1, 4]
;
Niewold, Timothy B.
[3]
Total Authors: 6
|
| Affiliation: | [1] Univ Estadual Campinas, Sch Med Sci, Autoimmun Lab, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Grad Program Child & Adolescent Hlth, Campinas, SP - Brazil
[3] NYU, Sch Med, Colton Ctr Autoimmun, New York, NY - USA
[4] Univ Estadual Campinas, Sch Med Sci, Dept Med, Rheumatol Unit, Campinas, SP - Brazil
Total Affiliations: 4
|
| Document type: | Review article |
| Source: | CURRENT OPINION IN IMMUNOLOGY; v. 67, p. 87-94, DEC 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Type I interferon (IFN) is a primary pathogenic factor in systemic lupus erythematosus (SLE). Gain-of-function genetic variants in the type I IFN pathway have been associated with risk of disease. Common polygenic as well as rare monogenic influences on type I IFN have been demonstrated, supporting a complex genetic basis for high IFN in many SLE patients. Both SLE-associated autoantibodies and high type I IFN can be observed in the pre-disease state. Patients with SLE and evidence of high type I IFN have more active disease and a greater propensity to nephritis and other severe manifestations. Despite the well-established association between type I IFN and SLE, the specific triggers of type I IFN production, the mechanisms by which IFNs help perpetuate the cycle of autoreactive cells and autoantibody production are not completely clear. This review provides an updated overview of type I IFN in SLE pathogenesis, clinical manifestations, and current therapeutic strategies targeting this pathway. (AU) | |
| FAPESP's process: | 08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus |
| Grantee: | Simone Appenzeller |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/23269-3 - MicroRNAs of TNFa gene in systemic lupus erythematosus: potential biomarkers |
| Grantee: | Mariana Postal Zink de Souza |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |