Network vaccinology

Autor(es)

Creighton, Rachel ^[1] ; Schuch, Viviane ^[2] ; Urbanski, Alysson H. ^[2] ; Giddaluru, Jeevan ^{[2, 3]} ; Costa-Martins, Andre G. ^{[2, 3]} ; Nakaya, I, Helder

Afiliação do(s) autor(es)

^[1] Univ Washington, Dept Bioengn, Seattle, WA - USA

^[2] I, Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil

^[3] I, Univ Sao Paulo, Sci Platform Pasteur, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: SEMINARS IN IMMUNOLOGY; v. 50, AUG 2020.
• Citações Web of Science: 0

Resumo

The structure and function of the immune system is governed by complex networks of interactions between cells and molecular components. Vaccination perturbs these networks, triggering specific pathways to induce cellular and humoral immunity. Systems vaccinology studies have generated vast data sets describing the genes related to vaccination, motivating the use of new approaches to identify patterns within the data. Here, we describe a framework called Network Vaccinology to explore the structure and function of biological networks responsible for vaccine-induced immunity. We demonstrate how the principles of graph theory can be used to identify modules of genes, proteins, and metabolites that are associated with innate and adaptive immune responses. Network vaccinology can be used to assess specific and shared molecular mechanisms of different types of vaccines, adjuvants, and routes of administration to direct rational design of the next generation of vaccines. (AU)

• Processo FAPESP: 18/14933-2 - Biologia integrativa aplicada à saúde humana
• Beneficiário: Helder Takashi Imoto Nakaya
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2
• Processo FAPESP: 17/27131-9 - Estratégia integrada para o estudo de agentes infecciosos causadores de doenças emergentes e/ou negligenciadas transmitidas por vetores de impacto global
• Beneficiário: Paola Marcella Camargo Minoprio
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/08216-2 - CPDI - Centro de Pesquisa em Doenças Inflamatórias
• Beneficiário: Fernando de Queiroz Cunha
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 18/21934-5 - Estatística de redes: teoria, métodos e aplicações
• Beneficiário: André Fujita
• Modalidade de apoio: Auxílio à Pesquisa - Temático