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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Network vaccinology

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Author(s):
Creighton, Rachel [1] ; Schuch, Viviane [2] ; Urbanski, Alysson H. [2] ; Giddaluru, Jeevan [2, 3] ; Costa-Martins, Andre G. [2, 3] ; Nakaya, I, Helder
Total Authors: 6
Affiliation:
[1] Univ Washington, Dept Bioengn, Seattle, WA - USA
[2] I, Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil
[3] I, Univ Sao Paulo, Sci Platform Pasteur, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: SEMINARS IN IMMUNOLOGY; v. 50, AUG 2020.
Web of Science Citations: 0
Abstract

The structure and function of the immune system is governed by complex networks of interactions between cells and molecular components. Vaccination perturbs these networks, triggering specific pathways to induce cellular and humoral immunity. Systems vaccinology studies have generated vast data sets describing the genes related to vaccination, motivating the use of new approaches to identify patterns within the data. Here, we describe a framework called Network Vaccinology to explore the structure and function of biological networks responsible for vaccine-induced immunity. We demonstrate how the principles of graph theory can be used to identify modules of genes, proteins, and metabolites that are associated with innate and adaptive immune responses. Network vaccinology can be used to assess specific and shared molecular mechanisms of different types of vaccines, adjuvants, and routes of administration to direct rational design of the next generation of vaccines. (AU)

FAPESP's process: 18/14933-2 - Integrative biology applied to human health
Grantee:Helder Takashi Imoto Nakaya
Support type: Research Grants - Young Investigators Grants - Phase 2
FAPESP's process: 17/27131-9 - Integrated strategy for the study of infectious agents causing emerging and/or neglected diseases transmitted by vectors of global impact
Grantee:Paola Marcella Camargo Minoprio
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/08216-2 - CRID - Center for Research in Inflammatory Diseases
Grantee:Fernando de Queiroz Cunha
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 18/21934-5 - Network statistics: theory, methods, and applications
Grantee:André Fujita
Support type: Research Projects - Thematic Grants