Integrated strategy for the study of infectious agents causing emerging and/or neglected diseases transmitted by vectors of global impact

• Grant number: 17/27131-9
• Support type: Research Projects - Thematic Grants
• Duration: July 01, 2019 - June 30, 2024
• Field of knowledge: Interdisciplinary Subjects
• Principal researcher: Paola Marcella Camargo Minoprio
• Grantee: Paola Marcella Camargo Minoprio
• Home Institution: Plataforma Científica Pasteur. Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Assoc. researchers: Edison Luiz Durigon ; Eduardo Massad ; Helder Takashi Imoto Nakaya ; Paolo Marinho de Andrade Zanotto ; Patricia Cristina Baleeiro Beltrão Braga
• Associated grant(s): 19/19852-3 - Multiuser equipment approved in grant number 2017/27131-9 : image system Newton 70 FT 400 with anesthetic system Biosthesia and accessories- Vilber, AP.EMU
• Associated scholarship(s): 22/08342-7 - Interaction of pathogenic microorganisms that trigger brain pathologies, specifically Trypanosoma vivax, Zika Virus and SARS-CoV-2 with experimental hosts, BP.PD; 21/08542-3 - Integrated strategy for the study of infectious agents that cause emerging and/or neglected diseases transmitted by vectors of global impact, BP.TT; 21/08553-5 - Integrated strategy for the study of infectious agents that cause emerging and/or neglected diseases transmitted by vectors of global impact, BP.TT; + associated scholarships 21/04914-3 - Modeling of congenital disease caused by the Zika Virus in the CNS in 2D/3D models: the initial objective, in addition to the Zika Virus, was expanded to study aspects related to the SARS-COV-2 Coronavirus, BP.PD; 19/24518-5 - Integrated strategy for the study of infectious agents causing emerging and/or neglected diseases transmitted by national and regional impact vectors, BP.PD; 19/20708-4 - Impact of Trypanosoma vivax infections on blood brain barrier crossing / disruption in murine systems, BP.PD - associated scholarships

Abstract

This new Pasteur/USP partnership is particularly focused on vector-borne emergent and neglected diseases that may cause very complex immune responses and serious anomalies and/or disturbances in the nervous system, consequently impacting animal and public health. These partners will join their forces in a new Scientific Platform, in the recent "Innovation Center InovaUSP", in spaces strategically designed to implement a novel model for performing scientific research in proximity to the academy. The technological objective of this Platform is to strengthen the development of joint initiatives with a high degree of infrastructures and state-of-the-art equipment, sharing expertise, technologies and know-how, in view of joint and innovative discoveries of products and processes. This project is structured around complementary research programs of 3 groups of researchers from the two institutions that, in concert through this task force, intend to strengthen their scientific ties by answering questions of medical and veterinary interest in this unique strategic environment. The project aims to achieve the following main scientific objectives: (i) generate luminous and fluorescent microorganisms to allow the real-time and detailed analysis of the interaction of these microorganisms with their hosts; (ii) to decipher immune, inflammatory and pathogenetic mechanisms triggered by these infectious agents, notably in the brain; (iii) build a database from the integration of results generated by Omics, Molecular biology and Immunology and; (iv) identify new targets for the development of preventive, diagnostic/prognostic and therapeutic methods. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CREIGHTON, RACHEL; SCHUCH, VIVIANE; URBANSKI, ALYSSON H.; GIDDALURU, JEEVAN; COSTA-MARTINS, ANDRE G.; NAKAYA, I, HELDER. Network vaccinology. SEMINARS IN IMMUNOLOGY, v. 50, AUG 2020. (18/14933-2, 17/27131-9, 13/08216-2, 18/21934-5)

CUNHA, MARIELTON DOS PASSOS; VILELA, ANA PAULA PESSOA; MOLINA, CAMILA VIEIRA; ACUNA, STEPHANIE MAIA; MUXEL, SANDRA MARCIA; BARROSO, VINICIUS DE MORAIS; BARONI, SABRINA; GOMES DE OLIVEIRA, LILIAN; ANGELO, YAN DE SOUZA; PERON, JEAN PIERRE SCHATZMANN; et al. Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient. FRONTIERS IN MEDICINE, v. 8, NOV 26 2021. (19/20708-4, 18/11612-0, 17/27131-9, 19/24518-5, 17/23519-2, 20/01487-4)