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Integrated strategy for the study of infectious agents causing emerging and/or neglected diseases transmitted by national and regional impact vectors

Grant number: 19/24518-5
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): February 01, 2020
Effective date (End): January 31, 2024
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Paola Marcella Camargo Minoprio
Grantee:Marielton dos Passos Cunha
Host Institution: Plataforma Científica Pasteur. Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:17/27131-9 - Integrated strategy for the study of infectious agents causing emerging and/or neglected diseases transmitted by vectors of global impact, AP.TEM

Abstract

We have established and validated innovative imaging technologies to visualize the dynamics of trypanosomal infection and pathology in vertebrate hosts or in vitro cellular infection processes. In this new stage we are proposing to study the dynamics of ZIKV infection with the use of quantitative bioluminescence and/or fluorescence images with spatial resolution of two- and three-dimensions combined with bioinformatics techniques to optimize in vitro and in vivo studies, in particular during brain impairment, using adapted models. The strategy is challenging and will better understand the virus-host interaction by building a bioluminescent/fluorescent ZIKV-BR strain, applying imaging tools and bioinformatics. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KAWASHIMA, IRINA YURI; NEGRET LOPEZ, MARIA CLAUDIA; CUNHA, MARIELTON DOS PASSOS; HASHIMOTO, RONALDO FUMIO. SARS-CoV-2 host prediction based on virus-host genetic features. SCIENTIFIC REPORTS, v. 12, n. 1, p. 9-pg., . (15/22308-2, 19/24518-5)
CUNHA, MARIELTON DOS PASSOS; VILELA, ANA PAULA PESSOA; MOLINA, CAMILA VIEIRA; ACUNA, STEPHANIE MAIA; MUXEL, SANDRA MARCIA; BARROSO, VINICIUS DE MORAIS; BARONI, SABRINA; GOMES DE OLIVEIRA, LILIAN; ANGELO, YAN DE SOUZA; PERON, JEAN PIERRE SCHATZMANN; et al. Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient. FRONTIERS IN MEDICINE, v. 8, . (19/20708-4, 18/11612-0, 17/27131-9, 19/24518-5, 17/23519-2, 20/01487-4)

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