Association between light exposure and metabolic syndrome in a rural Brazilian town

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Benedito-Silva, Ana Amelia ^[1] ; Evans, Simon ^[2] ; Mendes, Juliana Viana ^[1] ; Castro, Juliana ^[1] ; Goncalves, Bruno da Silva B. ^[1] ; Ruiz, Francieli S. ^{[2, 3]} ; Beijamini, Felipe ^{[3, 4]} ; Evangelista, Fabiana S. ^[1] ; Vallada, Homero ^[3] ; Krieger, Jose Eduardo ^[4] ; von Schantz, Malcolm ^[2] ; Pereira, Alexandre C. ^[5] ; Pedrazzoli, Mario ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo - Brazil

^[2] Univ Surrey, Fac Hlth & Med Sci, Guildford, Surrey - England

^[3] Univ Sao Paulo, Inst Psychiat, Med Sch, Sao Paulo - Brazil

^[4] Fed Univ Fronteira Sul UFFS, Realeza - Brazil

^[5] Univ Sao Paulo, Heart Inst InCor, Lab Genet & Mol Cardiol, Med Sch, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 15, n. 9 SEP 18 2020.
• Citações Web of Science: 0

Resumo

Context Metabolic syndrome (MetS) is a complex condition comprising a `clustering' of components representing cardiometabolic risk factors for heart disease and diabetes; its prevalence rate is high and consequences serious. Evidence suggests that light exposure patterns and misalignment of circadian rhythms might contribute to MetS etiology by impacting energy metabolism and glucose regulation. Objective We hypothesised that individuals with MetS would show disrupted circadian and sleep parameters alongside differences in light exposure profiles. We investigated this using data from a cohort study in Brazil. Methods Data from 103 individuals from the Baependi Heart Cohort Study aged between 50 and 70 were analysed. Motor activity and light exposure were measured using wrist-worn actigraphy devices. Cardiometabolic data were used to calculate the number of MetS components present in each participant, and participants grouped as MetS/non-MetS according to standard guidelines. Between-group comparisons were made for the actigraphy measures; additionally, correlation analyses were conducted. Results Motor activity and circadian profiles showed no differences between groups. However, the MetS group presented lower light exposure during the day and higher light exposure at night. Correlation analyses, including all participants, showed that greater daytime light exposure and greater light exposure difference between day and night were associated with reduced MetS risk (a lower number of MetS components). Also, the light exposure difference between day and night correlated with body mass index across all participants. Conclusions The observed results suggest a direct association between light exposure and MetS which appears to not be attributable to disruptions in circadian activity rhythm nor to sleep parameters. This link between light exposure patterns and MetS risk could inform possible prevention strategies. (AU)

• Processo FAPESP: 10/51010-8 - Estudos de associacao genomica ampla de fatores de risco associados a doencas cardiovasculares em uma amostra populacional brasileira.
• Beneficiário: Andréa Roseli Vançan Russo Horimoto
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/17368-0 - Genômica cardiovascular: mechanismos & novas terapias - CVGen mech2ther
• Beneficiário: José Eduardo Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Temático