The relevance of anti-Jo-1 autoantibodies in patients with definite dermatomyositis

Autor(es)

de Andrade, Vanessa Posener ^[1] ; De Souza, Fernando Henrique Carlos ^[1] ; Behrens Pinto, Gustavo Luiz ^[1] ; Shinjo, Samuel Katsuyuki ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med FMUSP, Div Rheumatol, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Med, Disciplina Reumatol, Av Dr Arnaldo 455, 3 Andar, Sala 3184, BR-01246903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ADVANCES IN RHEUMATOLOGY; v. 61, n. 1 FEB 19 2021.
• Citações Web of Science: 0

Resumo

Background To assess the prevalence and clinical relevance of anti-Jo-1 autoantibodies in a representative sample of patients with definite dermatomyositis (DM). Methods This retrospective cohort study took place from 2005 to 2020 and assessed 118 adult patients from a tertiary center who were diagnosed with definite DM. A commercial kit was used to detect anti-Jo-1 autoantibodies. Results The presence of anti-Jo-1 autoantibodies was observed in 10 out of 118 (8.5%) patients with definite DM. The following variables were comparable between individuals with and without anti-Jo-1 autoantibodies: age at diagnosis, sex, ethnicity, disease duration, follow-up period, recurrence rate, complete clinical response, death rate, and cancer incidence. There was no difference in clinical features between groups, except for an increased prevalence of ``mechanic's hands,{''} joint involvement, and lung disease, as well as a reduced occurrence of skin findings in patients positive for anti-Jo-1 autoantibodies. No anti-Jo-1-positive patients went into remission; they required greater use of glucocorticoids and immunosuppressive drugs. Conclusions Anti-Jo-1 positivity was found in 8.5% of patients with definite DM. This autoantibody was associated with an antisynthetase syndrome phenotype and might predict clinical outcomes in patients with definite DM. (AU)

• Processo FAPESP: 14/09079-1 - Impacto de corticoterapia no processo inflamatório de biópsia muscular de dermatomiosite e polimiosite
• Beneficiário: Samuel Katsuyuki Shinjo
• Modalidade de apoio: Auxílio à Pesquisa - Regular