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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The relevance of anti-Jo-1 autoantibodies in patients with definite dermatomyositis

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de Andrade, Vanessa Posener [1] ; De Souza, Fernando Henrique Carlos [1] ; Behrens Pinto, Gustavo Luiz [1] ; Shinjo, Samuel Katsuyuki [1, 2]
Total Authors: 4
[1] Univ Sao Paulo, Fac Med FMUSP, Div Rheumatol, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Disciplina Reumatol, Av Dr Arnaldo 455, 3 Andar, Sala 3184, BR-01246903 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ADVANCES IN RHEUMATOLOGY; v. 61, n. 1 FEB 19 2021.
Web of Science Citations: 0

Background To assess the prevalence and clinical relevance of anti-Jo-1 autoantibodies in a representative sample of patients with definite dermatomyositis (DM). Methods This retrospective cohort study took place from 2005 to 2020 and assessed 118 adult patients from a tertiary center who were diagnosed with definite DM. A commercial kit was used to detect anti-Jo-1 autoantibodies. Results The presence of anti-Jo-1 autoantibodies was observed in 10 out of 118 (8.5%) patients with definite DM. The following variables were comparable between individuals with and without anti-Jo-1 autoantibodies: age at diagnosis, sex, ethnicity, disease duration, follow-up period, recurrence rate, complete clinical response, death rate, and cancer incidence. There was no difference in clinical features between groups, except for an increased prevalence of ``mechanic's hands,{''} joint involvement, and lung disease, as well as a reduced occurrence of skin findings in patients positive for anti-Jo-1 autoantibodies. No anti-Jo-1-positive patients went into remission; they required greater use of glucocorticoids and immunosuppressive drugs. Conclusions Anti-Jo-1 positivity was found in 8.5% of patients with definite DM. This autoantibody was associated with an antisynthetase syndrome phenotype and might predict clinical outcomes in patients with definite DM. (AU)

FAPESP's process: 14/09079-1 - Impact of corticosteroids in the inflammatory process of muscle biopsies of dermatomyositis and polymyositis
Grantee:Samuel Katsuyuki Shinjo
Support type: Regular Research Grants