Phenolic compounds from jaboticaba (Plinia jaboticaba (Vell.) Berg) ameliorate intestinal inflammation and associated endotoxemia in obesity

Autor(es)

Rodrigues, Larissa ^[1] ; Donado-Pestana, Carlos M. ^[1] ; Moura, Marcio H. C. ^[1] ; Rossi e Silva, Rafaela ^[1] ; Pessoa, Erika V. M. ^[1] ; Genovese, Maria Ines ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Alimentos & Nutr Expt, Ave Prof Lineu Prestes, 580, Bloco 14, BR-05508900 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food Research International; v. 141, MAR 2021.
• Citações Web of Science: 0

Resumo

Jaboticaba (Plinia jaboticaba (Vell.) Berg) is a Brazilian native fruit belonging to the Myrtaceae family. Previously it was demonstrated that phenolic-rich extracts from jaboticaba (PEJ) possess health-beneficial properties in diet-induced obesity; however, whether PEJ modulates the obesity-associated intestinal inflammatory status remains unclear. Thus, male C57BL/6J obese mice were fed a high-fat-sugar (HFS) diet and received PEJ at two doses, 50 mg gallic acid equivalent (GAE)/kg body weight (BW) (PEJ1 group), and 100 mg GAE/kg BW (PEJ2 group), or water (HFS group) by oral gavage for 14 weeks. PEJ groups presented a reduced body weight gain and adiposity and were protected against insulin resistance and dyslipidemia. In addition, PEJ prevented metabolic endotoxemia linked to an attenuation of the HFS diet-induced intestinal inflammation via down-regulation of pro-inflammatory mediators such as tumor necrosis factor (TNF-alpha), membrane transporter toll-like receptor-4 (TLR-4) and nuclear factor-kappa B (NF-kappa B) in the colon. These anti-inflammatory effects appear to be involved, at least in part, with an inhibition of the colonic inflammasome pathway of obese mice. (AU)

• Processo FAPESP: 18/24477-4 - Modulação da microbiota intestinal e análise proteômica tecidual na inflamação e resistência à insulina induzidas pela obesidade: Papel dos polifenóis de frutos nativos brasileiros da família das mirtáceas
• Beneficiário: Maria Ines Genovese Rodriguez
• Modalidade de apoio: Auxílio à Pesquisa - Regular