Unraveling the epigenetic landscape of glomerular cells in kidney disease

Autor(es)

Pereira, Beatriz Maria Veloso ^[1] ; Katakia, Yash T. ^[2] ; Majumder, Syamantak ^[2] ; Thieme, Karina ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, Lab Bases Celulares & Mol Fisiol Renal, Sao Paulo, SP - Brazil

^[2] Birla Inst Technol & Sci BITS Pilani, Dept Biol Sci, Pilani Campus, Pilani, Rajasthan - India

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF MOLECULAR MEDICINE-JMM; v. 99, n. 6 MAR 2021.
• Citações Web of Science: 0

Resumo

Chronic kidney disease (CKD) is a major public health concern and its prevalence and incidence are rising quickly. It is a non-communicable disease primarily caused by diabetes and/or hypertension and is associated with high morbidity and mortality. Despite decades of research efforts, the pathogenesis of CKD remains a puzzle with missing pieces. Understanding the cellular and molecular mechanisms that govern the loss of kidney function is crucial. Abrupt regulation of gene expression in kidney cells is apparent in CKD and shown to be responsible for disease onset and progression. Gene expression regulation extends beyond DNA sequence and involves epigenetic mechanisms including changes in DNA methylation and post-translational modifications of histones, driven by the activity of specific enzymes. Recent advances demonstrate the essential participation of epigenetics in kidney (patho)physiology, as its actions regulate both the integrity of cells but also triggers deleterious signaling pathways. Here, we review the known epigenetic processes regulating the complex filtration unit of the kidney, the glomeruli. The review will elaborate on novel insights into how epigenetics contributes to cell injury in the CKD setting majorly focusing on kidney glomerular cells: the glomerular endothelial cells, the mesangial cells, and the specialized and terminally differentiated podocyte cells. (AU)

• Processo FAPESP: 19/10583-0 - Regulação epigenética de proteínas TET e Klotho na Doença Glomerular
• Beneficiário: Beatriz Maria Veloso Pereira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/00573-4 - O papel da (hidroxi)metilação do DNA na disfunção de podócitos: perspectivas epigenéticas para o tratamento da Doença Renal Crônica
• Beneficiário: Karina Thieme
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores