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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Step by Step about Germ Cells Development in Canine

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Autor(es):
de Souza, Aline Fernanda [1] ; Pieri, Naira Caroline Godoy [1] ; Martins, Daniele dos Santos [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, BR-13635900 Pirassununga - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo de Revisão
Fonte: ANIMALS; v. 11, n. 3 MAR 2021.
Citações Web of Science: 0
Resumo

Simple Summary The progression of germ cells is a remarkable event that allows biological discovery in the differ-entiation process during in vivo and in vitro development. This is crucial for understanding one toward making oogenesis and spermatogenesis. Companion animals, such as canine, could offer new animal models for experimental and clinical testing for translation to human models. In this review, we describe the latest and more relevant findings on germ cell development. In addition, we showed the methods available for obtaining germ cells in vitro and the characterization of pri-mordial germ cells and spermatogonial stem cells. However, it is necessary to further conduct basic research in canine to clarify the beginning of germ cell development. Primordial germ cells (PGCs) have been described as precursors of gametes and provide a connection within generations, passing on the genome to the next generation. Failures in the formation of gametes/germ cells can compromise the maintenance and conservation of species. Most of the studies with PGCs have been carried out in mice, but this species is not always the best study model when transposing this knowledge to humans. Domestic animals, such as canines (canine), have become a valuable translational research model for stem cells and therapy. Furthermore, the study of canine germ cells opens new avenues for veterinary reproduction. In this review, the objective is to provide a comprehensive overview of the current knowledge on canine germ cells. The aspects of canine development and germ cells have been discussed since the origin, specifications, and development of spermatogonial canine were first discussed. Additionally, we discussed and explored some in vitro aspects of canine reproduction with germ cells, such as embryonic germ cells and spermatogonial stem cells. (AU)

Processo FAPESP: 12/05609-0 - Espermatogênese xenogênica pós-transplante de células tronco caninas no testículo de camundongos
Beneficiário:Naira Caroline Godoy Pieri
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 14/26761-0 - Reprogramação de células germinativas embrionárias humanas
Beneficiário:Aline Fernanda de Souza
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 19/09148-7 - Caracterização de células multipotentes oriundas do folículo de penas como fonte para criação de um banco de recursos genéticos de aves silvestres
Beneficiário:Daniele dos Santos Martins
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/10542-5 - Epigenética da reprogramação em células germinativas embrionárias caninas
Beneficiário:Aline Fernanda de Souza
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 16/15260-6 - Identificação e rota de migração das células germinativas primordiais caninas
Beneficiário:Eloise Cristina de Ramos
Linha de fomento: Bolsas no Brasil - Iniciação Científica